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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v7.i3.750
435 pages

A Study on the Effect of Ganoderma lucidum (W.Curt.: Fr.) Lloyd in Indian HIV Carriers

S. Mohan
KMCH College of Pharmacy and Institute of Laboratory Medicine, Kovai Medical Center and Hospital, Coimbatore 641 014, India
P. Chinnaswamy
KMCH College of Pharmacy and Institute of Laboratory Medicine, Kovai Medical Center and Hospital, Coimbatore 641 014, India
A. S. Krishnamoorthy
Department of Plant Pathology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India

RÉSUMÉ

Over the past decade, substantial progress has been made in defining strategies for treatment of disease caused by human immunodeficiency virus (HIV), in which natural products can serve as a source of structurally novel chemicals that are worth investigating as specific inhibitors of HIV as well as its essential enzymes, protease (PR), and reverse transcriptase (RT). Therefore, it is necessary to identify and develop new anti-HIV agents without adverse side effects and viral resistance. Ganoderma lucidum (Reishi), belonging to the higher Basidiomycetes, appears to be very safe because oral administration of the extract did not display any toxicity. A literature survey revealed that the medicinal effect of G. lucidum was not investigated in India, and, hence, the present study was carried out to investigate the effect of supplementation of G. lucidum in Indian HIV carriers.
Ganoderma lucidum is one of the valuable crude drugs, which has been used in China and Japan as a traditional Chinese medicine or folk medicine for the treatment of various diseases. In the present study, 25 confirmed HIV-1 human subjects were selected based on the inclusion and exclusion criteria and administered with fruit body of G. lucidum for 90 days. Prior to and after 90 days of supplementation with G. lucidum, the level of HIV viral load, lymphocyte enumeration (percentage of CD3, CD4, CD8, and absolute CD4, CD8 counts), total leukocyte count, WBC differential count, and IgA, IgG, IgM, and liver function tests were estimated.
Estimation of HIV viral load revealed that viral load was not increased in HIV carriers after supplementation of G. lucidum, which indicates that the replication of the human immunodeficiency virus was inhibited in HIV carriers. But there was no significant decrease of HIV viral load. It was observed that the mean percentage of CD3 and CD8 were not changed significantly after supplementation, but the percentage of CD4 was significantly increased from 18.77 ± 3.25 to 23.89 ± 4.04. However, the increase was statistically significant (p < 0.01). Similarly, mean absolute CD8 count was not altered, but mean absolute CD4 count also increased from 211.60 ± 56.97 (cells/mL) to 355.60 ± 90.73 (cells/mL). This increase was statistically significant (p < 0.01). Total leukocyte count, WBC differential count, and IgA, IgM, and IgG levels were not altered significantly in HIV carriers. The results of liver function tests obtained also indicated that the supplementation of G. lucidum was harmless because they did not show any toxic effects in HIV carriers. It is concluded that the supplementation of G. lucidum mushroom may reduce the risk of developing AIDS in Indian HIV carriers.


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