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International Journal of Medicinal Mushrooms
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ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v7.i3.770
pages 437-438

Antimicrobial Colossolactones from a Nigerian Polypore Ganoderma colossum (Fr.) C.F. Baker

Lauretta N. Ofodile
Department of Biological Science, Yaba College of Technology, Yaba, Lagos, Nigeria
N. U. Uma
Department of Botany/Microbiology, University of Lagos, Akoka, Lagos, Nigeria
T. Kokubun
RoyaI Botanic Gardens, Kew, Richmond, Surrey, TW9 3AB, UK
Renee J. Grayer
RoyaI Botanic Gardens, Kew, Richmond, Surrey, TW9 3AB, UK
O. T. Ogundipe
Department of Botany/Microbiology, University of Lagos, Akoka, Lagos, Nigeria
Monnique S. J. Simmons
RoyaI Botanic Gardens, Kew, Richmond, Surrey, TW9 3AB, UK


A number of synthetic antimicrobial agents have been developed to kill microorganisms effectively. However, drug resistance often occurs when these agents are used long-term. As a result, there has been a tremendous interest in the antimicrobial properties of plants and fungi. Ganoderma species are widely used, especially in Asia, for the treatment of chronic diseases such as cancer, hepatitis, bronchitis, asthma, and haemorrhoids. Many publications have also described the antimicrobial properties of compounds isolated from various polypores, including Ganoderma species. Nigeria has a rich biota of polypores, but the antimicrobial activity of these fungi has not been reported previously.
The antimicrobial activity of a new colossolactone, 23-hydroxycokissolactone E, and two known colossolactones isolated from Ganoderma colossum (Ganodermataceae) were tested against gram-positive and gram-negative bacteria. Fruiting bodies of G. colossum were collected from a dead log of Delonix regia (Fabaceae), Yaba College of Technology, Lagos, Nigeria. The polypore was morphologically determined as G. colossum by the truncate, ornamental, yellow basidiospore that is 11−17 × 7−11 cm in diameter. A voucher specimen accession K (M) 120802 was deposited in the herbarium at the Royal Botanic Garden, Kew, UK. Bioassay guided fractionation of compounds from a fungal sample was carried out using various chromatographic techniques. A ground sample was extracted with 100 mL of n-hexane: dichloromethane. The residue was reconstituted in methanol and subjected to column chromatography. Seventeen fractions obtained were fractionated using analytical thin layer chromatography (TLC). Chromatograms were inspected under UV light at 254 and 366 nm.

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