Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
In Vitro Evaluation of the Antiviral Activity of Some Mushrooms from Turkey
Get access
RÉSUMÉ
Despite considerable recent work to reveal different features of mushrooms species, the few studies of antiviral activities are inadequate and therefore further studies are required. Morchella conica, M. esculenta, Terfezia boudieri, Pleurotus ostreatus, Tricholoma anatolicum, Fomes fomentarius, Laetiporus sulphureus, Phellinus igniarius, Porodaedalea pini, and Pyrofomes demidoffii from Turkey were investigated to reveal their in vitro cytotoxic and anti-herpes simplex virus 1 (HSV-1) activities. The crude methanol extracts (MEs) and aqueous extracts (AEs) of fungal species and acyclovir (ACV) were used. Various dilutions were used to assess the cytotoxic effects of fungal species (50-0.10 mg/mL) and ACV (500-0.98 μg/mL) on uninfected Vero cells. Maximum nontoxic concentrations were determined for all extracts and ACV by comparing the optical densities of their cell controls. The concentration providing 50% protection against the cytopathic effect caused by the virus, extracts, and ACV (EC50) was calculated, and the half-maximal cytotoxic concentration (CC50) and the selectivity index (SI) were determined, the latter as the ratio of CC50 to EC50. While the AEs of F. fomentarius (EC50, 11.22 mg/mL; SI > 4.46), Ph. igniarius (EC50, 9.71 mg/mL; SI > 5.15), and P. pini (EC50, 7.16 mg/mL; SI > 6.98) showed considerable antiherpetic activity, MEs and AEs of the other fungal species did not showed any effects. The EC50 and SI of ACV were determined as 0.20 μg/mL and 3085, respectively. The results demonstrate that F. fomentarius, Ph. igniarius, and P. pini have important anti-HSV-1 activity.
-
Badalyan Susanna M., Barkhudaryan Anush, Rapior Sylvie, Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application, in Medicinal Mushrooms, 2019. Crossref
-
Seetaha Supaphorn, Ratanabunyong Siriluk, Tabtimmai Lueacha, Choowongkomon Kiattawee, Rattanasrisomporn Jatuporn, Choengpanya Khuanjarat, Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms, Veterinary World, 13, 9, 2020. Crossref
-
Elhusseiny Shaza M., El-Mahdy Taghrid S., Awad Mohamed F., Elleboudy Nooran S., Farag Mohamed M. S., Aboshanab Khaled M., Yassien Mahmoud A., Antiviral, Cytotoxic, and Antioxidant Activities of Three Edible Agaricomycetes Mushrooms: Pleurotus columbinus, Pleurotus sajor-caju, and Agaricus bisporus, Journal of Fungi, 7, 8, 2021. Crossref
-
Elhusseiny Shaza M., El-Mahdy Taghrid S., Awad Mohamed F., Elleboudy Nooran S., Farag Mohamed M. S., Yassein Mahmoud A., Aboshanab Khaled M., Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms, Molecules, 26, 15, 2021. Crossref
-
Zhang Yu, Zhang Guoying, Ling Jianya, Medicinal Fungi with Antiviral Effect, Molecules, 27, 14, 2022. Crossref
-
Vazquez-Armenta Francisco Javier, Leyva Juan Manuel, Mata-Haro Veronica, Gonzalez-Aguilar Gustavo A., Cruz-Valenzuela Manuel R., Esqueda Martin, Gutierrez Aldo, Nazzaro Filomena, Fratianni Florinda, Gaitán-Hernández Rigoberto, Ayala-Zavala J. Fernando, Phenolic compounds of Phellinus spp. with antibacterial and antiviral activities, Brazilian Journal of Microbiology, 53, 3, 2022. Crossref
-
Zhou Xuebin, Shi Qiyuan, Li Jinhua, Quan Shengli, Zhang Xinyue, Gu Lili, Li Hongxing, Ju Yue, Hu Min, Li Qin, Medicinal fungus Phellinus igniarius alleviates gout in vitro by modulating TLR4/NF-kB/NLRP3 signaling, Frontiers in Pharmacology, 13, 2022. Crossref
-
He Peixin , Chen Zhuo , Men Ying , Wang Miaomiao , Wang Wensheng , Liu Wei , Activity Assay of Amylase and Xylanase Is Available for Quantitative Assessment of Strain Aging in Cultivated Culinary-Medicinal Morchella Mushrooms (Ascomycotina) , International Journal of Medicinal Mushrooms, 25, 1, 2023. Crossref