Abonnement à la biblothèque: Guest
International Journal of Physiology and Pathophysiology

Publication de 4  numéros par an

ISSN Imprimer: 2155-014X

ISSN En ligne: 2155-0158

SJR: 0.116

Involvement of Some Subtypes of 5-HT2-Receptors in Affective Behavior in Female Rats

Volume 5, Numéro 1, 2014, pp. 41-47
DOI: 10.1615/IntJPhysPathophys.v5.i1.40
Get accessGet access

RÉSUMÉ

The present work was devoted to a comparative analysis of the contribution of 5-HT2 receptors to the mechanisms of anxiety and depressive-like behavior under natural cyclical fluctuations in the content of sexual hormones in adult female rats. Effects of chronic administration of m-CPP, 5-HT2B2C receptor agonist (0.5 mg/kg, i.p) and ketanserine, 5-HT2A2C receptor antagonist (0.1 mg/kg, i.p) for 14 days, on the anxiety and depressive-like behavior were studied in adult female rats. It has been shown that chronic ketanserine administration rendered antidepressant and anxiolytic effects in females during estrous and proestrous phases. Administration of m-CPP also resulted in antidepressant effect in those phases. In particular, distinct modulation of anxiety behavior depending on the rat ovarian cycle phases was observed. The results obtained suggest that different subtypes of 5-HT receptors contribute to the mechanisms of anxiety and depressive-like behavior at alterations of hormonal balance during the ovarian cycle. They indicate a close interaction of the ovarian, hormonal and serotonergic systems of the brain in mechanisms of anxiety and depression.

Dernier numéro

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain