Volume 1,
Numéro 3, 2010,
pp. 227-234
DOI: 10.1615/IntJPhysPathophys.v1.i3.40
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Roman I. Yanchii
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana Yu. Voznesenska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olena A. Shepel
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana M. Bryzgina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Vera S. Sukhina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
L. M. Lazarenko
Kyiv Taras Shevchenko National University, Kyiv, Ukraine
Z. M. Olenivska
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
Mykola Ya. Spivak
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
R. M. Serbenjuk
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
O. M. Serdyuk
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
RÉSUMÉ
Several ovarian disorders in women are associated with autoimmune factors. In this study it was investigated a level of cytokines − TNF-α and IFNs in ovarian homogenate and blood serum at ovarian autoimmune damage of mammals. Experimental immune ovarian failure was induced in CBA mice by either immunization with allogenic ovarian extracts or administration of xenogenic anti-ovarian antibodies. Both models were accompanied with abnormalities in production immunoregulatory cytokines. These data confirm importance of definition of proinflammatory cytokine level for disclosing immune mechanisms which lay in a pathogenesis autoimmune ovarian diseases of female reproductive organs.