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International Journal of Physiology and Pathophysiology

Publication de 4  numéros par an

ISSN Imprimer: 2155-014X

ISSN En ligne: 2155-0158

SJR: 0.116

Production of Immunoregulatory Cytokines at Autoimmune Damage of Mammalian Ovaries

Volume 1, Numéro 3, 2010, pp. 227-234
DOI: 10.1615/IntJPhysPathophys.v1.i3.40
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RÉSUMÉ

Several ovarian disorders in women are associated with autoimmune factors. In this study it was investigated a level of cytokines − TNF-α and IFNs in ovarian homogenate and blood serum at ovarian autoimmune damage of mammals. Experimental immune ovarian failure was induced in CBA mice by either immunization with allogenic ovarian extracts or administration of xenogenic anti-ovarian antibodies. Both models were accompanied with abnormalities in production immunoregulatory cytokines. These data confirm importance of definition of proinflammatory cytokine level for disclosing immune mechanisms which lay in a pathogenesis autoimmune ovarian diseases of female reproductive organs.

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