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Critical Reviews™ in Eukaryotic Gene Expression

Publication de 6  numéros par an

ISSN Imprimer: 1045-4403

ISSN En ligne: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy

Volume 22, Numéro 1, 2012, pp. 53-59
DOI: 10.1615/CritRevEukarGeneExpr.v22.i1.40
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RÉSUMÉ

Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.

CITÉ PAR
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  12. Han Chao, Li Zhongrui, Hou Jiqin, Wang Zhen, Xu Dingqiao, Xue Guimin, Kong Lingyi, Bioactivity evaluation of natural product α-mangostin as a novel xanthone-based lysine-specific demethylase 1 inhibitor to against tumor metastasis, Bioorganic Chemistry, 76, 2018. Crossref

  13. LI YUANXIA, WAN XIAOLEI, WEI YE, LIU XIUWEN, LAI WENSHENG, ZHANG LIUPING, JIN JIE, WU CHAOYANG, SHAO QIXIANG, SHAO GENBAO, LIN QIONG, LSD1-mediated epigenetic modification contributes to ovarian cancer cell migration and invasion, Oncology Reports, 35, 6, 2016. Crossref

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  18. Lan Huiyin, Tan Mingjia, Zhang Qiang, Yang Fei, Li Hua, Xiong Xiufang, Sun Yi, LSD1 Destabilizes FBXW7 Independent of Its Demethylase Activity, SSRN Electronic Journal , 2018. Crossref

  19. Clark Erin A., Wu Feizhen, Chen Yirui, Kang Paco, Kaiser Ursula B., Fang Rui, Shi Yujiang G., GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers, Cell Reports, 27, 12, 2019. Crossref

  20. He Xingrui, Gao Yuan, Hui Zi, Shen Guodong, Wang Shuo, Xie Tian, Ye Xiang-Yang, 4-Hydroxy-3-methylbenzofuran-2-carbohydrazones as novel LSD1 inhibitors, Bioorganic & Medicinal Chemistry Letters, 30, 10, 2020. Crossref

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  29. Xi Jiayue, Xu Siyuan, Wu Liming, Ma Tianfang, Liu Rongfeng, Liu Yu-Chih, Deng Dawei, Gu Yueqing, Zhou Jinpei, Lan Fei, Zha Xiaoming, Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors, Bioorganic Chemistry, 72, 2017. Crossref

  30. Wang Shuai, Zhao Li-Jie, Zheng Yi-Chao, Shen Dan-Dan, Miao Er-Fei, Qiao Xue-Peng, Zhao Li-Juan, Liu Ying, Huang Ruilei, Yu Bin, Liu Hong-Min, Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors, European Journal of Medicinal Chemistry, 125, 2017. Crossref

  31. Ge Wenshu, Liu Yunsong, Chen Tong, Zhang Xiao, Lv Longwei, Jin Chanyuan, Jiang Yong, Shi Lei, Zhou Yongsheng, The epigenetic promotion of osteogenic differentiation of human adipose-derived stem cells by the genetic and chemical blockade of histone demethylase LSD1, Biomaterials, 35, 23, 2014. Crossref

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