Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.841 Facteur d'impact sur 5 ans: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013843
pages 203-207

Dual Protective and Cytotoxic Benefits of Mesenchymal Stem Cell Therapy in Combination with Chemotherapy/Radiotherapy for Cancer Patients

Fatemeh Hendijani
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
Shaghayegh Haghjooy Javanmard
Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

RÉSUMÉ

Cancer is a major health problem in the world, and scientists seek innovative treatment strategies with higher efficacy and lower toxicity than the existing therapeutic agents. In this way, stem cell researchers try to reveal new pathways that will eventually benefit patients. Stem cell research has proven that mesenchymal stem cells (MSCs) possess anticancer activities, and their protein-rich secretome showed similar effects. MSCs also secrete cytokines that play an active role in healing and regeneration processes. Because of their known plasticity, MSCs display a variety of characteristics and functions in different environments, depending on their interactions with various cell types and tissues. Therefore, we hypothesize that MSC therapy in combination with anticancer medicines can potentiate cytotoxic effects on cancer cells. In addition, because of their regenerative capacity, MSCs can protect normal tissues from adverse cytotoxic drug reactions. They may also help rescue injured tissues from these toxic damages or systemic pathological events that occur during cancer treatment. MSC therapy may double the beneficial effects on cancer and normal cells. As our knowledge of systems biology and biotechnological methodology is progressing, this idea can move forward as a treatment option.


Articles with similar content:

Characteristics and Tissue Regeneration Properties of Gingiva-Derived Mesenchymal Stem Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 2
Dehua Li, Zhengze Guo, Zhang Wu, Lei Qin, Ningbo Zhao
Oral Squamous Cell Carcinoma: Current Treatment Strategies and Nanotechnology-Based Approaches for Prevention and Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Munira Momin, Chintan Bhavsar, Sankalp A. Gharat
Regulation of Chemokine Expression in the Tumor Microenvironment
Critical Reviews™ in Immunology, Vol.34, 2014, issue 2
Anton V. Gorbachev, Robert L. Fairchild
Bone Tissue Engineering: Recent Advances and Challenges
Critical Reviews™ in Biomedical Engineering, Vol.40, 2012, issue 5
Syam P. Nukavarapu, Cato T. Laurencin, Ami R. Amini
COMMENTARY. Regulation of Drug and Immune Resistance by YY1 in Cancer
Forum on Immunopathological Diseases and Therapeutics, Vol.1, 2010, issue 1-2
James A. McCubrey, Maria C. Mazzarino, Natale D'Alessandro