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Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.841 Facteur d'impact sur 5 ans: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.20
pages 313-322

mTOR Regulates T-Cell Differentiation and Activation in Immunity and Autoimmunity

Yujing Bi
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing China
Guangwei Liu
Institute of Zoology, Chinese Academy of Science
Ruifu Yang
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing China

RÉSUMÉ

mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integrating environmental cues in the form of amino acids, energy, and growth factors. Recently, the kinase mTOR has emerged as an important regulator of the differentiation and function of helper T cells in immune responses and autoimmune diseases. In this review, we summarize the regulatory effects and mechanisms of mTOR complex in the differentiation of CD4+ T and CD8+ T cells, and T-cell homeostasis modulation. This should contribute to understanding the central role for mTOR in regulating immune responses and autoimmune diseases.


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