Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.841 Facteur d'impact sur 5 ans: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v8.i3-4.70
pages 377-393

The Molecular and Cellular Biology of Pancreatic Cancer

Richard A. Perugini
Department of Surgery, University of Massachusetts-Memorial Health System, Worcester, MA
Theodore P. McDade
Department of Surgery, University of Massachusetts-Memorial Health System, Worcester, MA
Frank J. Vittimberga, Jr.
Department of Surgery, University of Massachusetts-Memorial Health System, Worcester, MA
Mark P. Callery
Department of Surgery, University of Massachusetts-Memorial Health System, Worcester, MA

RÉSUMÉ

Adenocarcinoma of the pancreas carries a grave prognosis for affected patients. Certain oncogenes (K-ras and HER-2/neu) are mutated in a large proportion of these aggressive tumors. Adenocarcinoma of the pancreas has also been associated with loss of tumor suppressor genes (p53, DPC4, pl6/MTS), either by deletion or by mutation and loss of function. Growth factors (EGF, TGF-α, HGF) and growth factor receptors (EGF-R, c-met, CCK) are expressed at levels not found in the normal pancreas. Finally, factors important for angiogenesis (FGF, integrins, selectins) are likely to play an important role in the growth and metastasis of clinically relevant tumors. This review attempts to summarize and assimilate current research into the molecular and cellular biology of pancreatic cancer.


Articles with similar content:

Homeobox Gene Involvement in Normal Hematopoiesis and in the Pathogenesis of Childhood Leukemias
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 3-4
Vassilis Zoumpourlis, Ioannis Christodoulou, Maria Adamaki, Maria Goulielmaki, Spiros Vlahopoulos
The Novel Role of Yin Yang 1 in the Regulation of Epithelial to Mesenchymal Transition in Cancer Via the Dysregulated NF-κB/Snail/YY1/RKIP/PTEN Circuitry
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Stavroula Baritaki, Benjamin Bonavida
Possible Role of Epidermal Growth Factor Receptors in the Therapy of Pancreatic Cancer
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 4
R. S. R. Murthy, Suresh P. Vyas, Manish K. Gupta, Sahil Aggarwal, Swati Gupta
Resistance to Cell Death and Its Modulation in Cancer Stem Cells
Critical Reviews™ in Oncogenesis, Vol.21, 2016, issue 3-4
Ahmad R. Safa
Role of NF-κB in Tumorigenesis
Forum on Immunopathological Diseases and Therapeutics, Vol.4, 2013, issue 2
Gautam Sethi, Muthu K. Shanmugam, Alan P. Kumar, Benny K. H. Tan