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Critical Reviews™ in Eukaryotic Gene Expression

Publication de 6  numéros par an

ISSN Imprimer: 1045-4403

ISSN En ligne: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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The Amelogenin "Enamel Proteins" and Cells in the Periodontium

Volume 18, Numéro 4, 2008, pp. 345-360
DOI: 10.1615/CritRevEukarGeneExpr.v18.i4.30
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RÉSUMÉ

This overview will examine the multifunctional nature of a group of proteins known as the amelogenins. These secreted proteins were named in the 1960s because of their expected role during development of dental enamel [Eastoe JE. Adv Fluorine Res. 1965;21:5−17]. As gene expression assays became more sensitive, expression was also noted in tissues not involved with enamel formation leading to hypotheses concerning additional roles for these proteins. In vitro approaches led to the discovery that some of the amelogenins are able to regulate gene expression and to participate in cellular signaling. An extract containing predominately amelogenins has been used clinically in treatment of certain forms of pcriodontal disease with regenerative results noted originally in animal models, but later in human patients as well. Much literature has been devoted to the roles of amelogenins during mineral formation, and therefore this topic will be covered primarily in the Introduction. The goal of this review will be to focus on strategies that have been used to uncover roles of amelogenins related to gene expression and development apart from the roles in enamel mineral, and the possible functions that these proteins could have if delivered to normally nonexpressing tissues for therapeutic approaches.

CITÉ PAR
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