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Critical Reviews™ in Eukaryotic Gene Expression

Publication de 6  numéros par an

ISSN Imprimer: 1045-4403

ISSN En ligne: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Complex Smad-Dependent Transcriptional Responses in Vertebrate Development and Human Disease

Volume 12, Numéro 2, 2002, 18 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i2.20
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RÉSUMÉ

Smad proteins mediate genomic responses to polypeptides of the transforming growth factor type b (TGF-b) family, affecting cellular proliferation and differentiation, adhesion, and death. Members of one class of these Smad proteins, the receptor-regulated Smads or R-Smads, accumulate in the nucleus on their activation byligand-bound complexes of serine-threonine kinase receptors at the cell surface. These effector proteins then participate directly in the regulation of gene expression by binding to DNA, interacting with transcription factors, and recruiting corepressors or coactivators to specific promoters. Although many nuclear Smad-interacting factors were isolated during the last 3 years, the field has recently taken a step beyond the characterization of the activity of these Smad-containing complexes on gene expression in vitro, as it addresses now their contribution to many processes in vivo. We have selected examples of such recent progress to illustrate the remarkable variation in the molecular mechanisms underlying Smad-dependent signaling depending on the non-Smad partner in the nucleus and their relevance to normal embryogenesis and consequences of their deregulation in human disorders and pathology.

CITÉ PAR
  1. Liu Shi-Yong, Zhang Zhi-Yuan, Song Ye-Chun, Qiu Ke-Jun, Zhang Ke-Cheng, An Ning, Zhou Zheng, Cai Wen-Qin, Yang Hui, SVZa neural stem cells differentiate into distinct lineages in response to BMP4, Experimental Neurology, 190, 1, 2004. Crossref

  2. Zwijsen An, Verschueren Kristin, Huylebroeck Danny, New intracellular components of bone morphogenetic protein/Smad signaling cascades, FEBS Letters, 546, 1, 2003. Crossref

  3. Groneberg David A., Witt Heiko, Adcock Ian M., Hansen Gesine, Springer Jochen, SMADS AS INTRACELLULAR MEDIATORS OF AIRWAY INFLAMMATION, Experimental Lung Research, 30, 3, 2004. Crossref

  4. Rane Sushil G., Lin Huei-Min, Lee Ji-Hyeon, Transforming Growth Factor-β Signaling in Pancreas Development and Pancreatic Disease, in Transforming Growth Factor-β in Cancer Therapy, Volume II, 2008. Crossref

  5. Bertocchini Federica, Skromne Isaac, Wolpert Lewis, Stern Claudio D., Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo, Development, 131, 14, 2004. Crossref

  6. Birkhoff Judith C., Huylebroeck Danny, Conidi Andrea, ZEB2, the Mowat-Wilson Syndrome Transcription Factor: Confirmations, Novel Functions, and Continuing Surprises, Genes, 12, 7, 2021. Crossref

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