Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
Complex Smad-Dependent Transcriptional Responses in Vertebrate Development and Human Disease
RÉSUMÉ
Smad proteins mediate genomic responses to polypeptides of the transforming growth factor type b (TGF-b) family, affecting cellular proliferation and differentiation, adhesion, and death. Members of one class of these Smad proteins, the receptor-regulated Smads or R-Smads, accumulate in the nucleus on their activation byligand-bound complexes of serine-threonine kinase receptors at the cell surface. These effector proteins then participate directly in the regulation of gene expression by binding to DNA, interacting with transcription factors, and recruiting corepressors or coactivators to specific promoters. Although many nuclear Smad-interacting factors were isolated during the last 3 years, the field has recently taken a step beyond the characterization of the activity of these Smad-containing complexes on gene expression in vitro, as it addresses now their contribution to many processes in vivo. We have selected examples of such recent progress to illustrate the remarkable variation in the molecular mechanisms underlying Smad-dependent signaling depending on the non-Smad partner in the nucleus and their relevance to normal embryogenesis and consequences of their deregulation in human disorders and pathology.
-
Liu Shi-Yong, Zhang Zhi-Yuan, Song Ye-Chun, Qiu Ke-Jun, Zhang Ke-Cheng, An Ning, Zhou Zheng, Cai Wen-Qin, Yang Hui, SVZa neural stem cells differentiate into distinct lineages in response to BMP4, Experimental Neurology, 190, 1, 2004. Crossref
-
Zwijsen An, Verschueren Kristin, Huylebroeck Danny, New intracellular components of bone morphogenetic protein/Smad signaling cascades, FEBS Letters, 546, 1, 2003. Crossref
-
Groneberg David A., Witt Heiko, Adcock Ian M., Hansen Gesine, Springer Jochen, SMADS AS INTRACELLULAR MEDIATORS OF AIRWAY INFLAMMATION, Experimental Lung Research, 30, 3, 2004. Crossref
-
Rane Sushil G., Lin Huei-Min, Lee Ji-Hyeon, Transforming Growth Factor-β Signaling in Pancreas Development and Pancreatic Disease, in Transforming Growth Factor-β in Cancer Therapy, Volume II, 2008. Crossref
-
Bertocchini Federica, Skromne Isaac, Wolpert Lewis, Stern Claudio D., Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo, Development, 131, 14, 2004. Crossref
-
Birkhoff Judith C., Huylebroeck Danny, Conidi Andrea, ZEB2, the Mowat-Wilson Syndrome Transcription Factor: Confirmations, Novel Functions, and Continuing Surprises, Genes, 12, 7, 2021. Crossref