Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.841 Facteur d'impact sur 5 ans: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v19.i2.20
pages 109-124

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

Clifford J. Rosen
Maine Medical Center Research Institute, USA
Cheryl Ackert-Bicknell
The Jackson Laboratory, Bar Harbor ME 04609, USA
Juan Pablo Rodriguez
The University of Chile, Santiago, Chile
Ana Maria Pino
The University of Chile, Santiago, Chile

RÉSUMÉ

Bone marrow adipogenesis is a normal physiologic process in all mammals. However, its function is unknown. The mesenchymal stem cell is the marrow precursor for adipocytes as well as osteoblasts, and PPARG is an essential differentiation factor for entrance into the fat lineage. Mouse models have provided significant insight into the molecular cues that define stromal cell fate. In humans, accelerated marrow adipogenesis has been associated with aging and several chronic conditions, including diabetes mellitus and osteoporosis. Newer imaging techniques have been used to determine the developmental time course of fat generation in bone marrow. However, more studies are needed to understand the interrelationship among hematopoietic, osteoblastic, and adipogenic cells within the marrow niche.


Articles with similar content:

Role of DLX Regulatory Proteins in Osteogenesis and Chondrogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 3
Giovanni Levi, Marie-Christine de Vernejoul, Nadeem Samee
Pathophysiology and Genetics of Metabolic Bone Disorders Characterized by Increased Bone Turnover
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 3
Greet Beyens, Wim Van Hul
Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 1
Shuying Yang, Wei Chen, Carrie S. Soltanoff, Yi-Ping Li
Responsiveness of Osteoblastic and Osteolytic Bone Metastases to Vitamin D Analogs
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 2
Sara Peleg
Acquired T-Cell Immunodeficiency in Thymoma Patients
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Paul Fisch, Petros Christopoulos