Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
Transcriptional Control Mechanisms in the Regulation of Cholesterol Balance
RÉSUMÉ
The mechanisms that govern regulation of cholesterol metabolism in higher eukaryotic cells provide an example of how metabolic regulation has evolved to establish growth and nutritional control in a multicellular environment. Two sources of cholesterol must be balanced to ensure optimum growth and viability. Much of the control is established by regulating the levels of key proteins involved in cholesterol uptake and biosynthesis and this occurs by alterations in promoter activity. The studies discussed here track the progression in understanding the mechanism for transcriptional regulation by cholesterol from the isolation of the key genes involved, to the careful dissection of the cis-acting sequences that control expression, and on to what is currently known about the trans-acting proteins that mediate the regulatory response.
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Szkopińska Anna, Świeżewska Ewa, Karst Francis, The Regulation of Activity of Main Mevalonic Acid Pathway Enzymes: Farnesyl Diphosphate Synthase, 3-Hydroxy-3-methylglutaryl-CoA Reductase, and Squalene Synthase in Yeast Saccharomyces cerevisiae, Biochemical and Biophysical Research Communications, 267, 1, 2000. Crossref
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Middleton Aliya, Nury David, Willington Susan J, Latif Liaque, Hill Stephen J, Middleton Bruce, Modulation by cellular cholesterol of gene transcription via the cyclic AMP response element11Abbreviations: cAMP, adenosine 3′,5′-cyclic monophosphate; CHO, Chinese hamster ovary; CRE, cyclic AMP response element; FBS, foetal bovine serum; MβCD, methyl-beta-cyclodextrin: PKA, protein kinase A; SPAP, secreted placental alkaline phosphatase., Biochemical Pharmacology, 62, 2, 2001. Crossref
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Ong W.Y, Hu C.Y, Soh Y.P, Lim T.M, Pentchev P.G, Patel S.C, Neuronal localization of sterol regulatory element binding protein-1 in the rodent and primate brain: a light and electron microscopic immunocytochemical study, Neuroscience, 97, 1, 2000. Crossref
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Kim Young-Chae, Byun Sangwon, Zhang Yang, Seok Sunmi, Kemper Byron, Ma Jian, Kemper Jongsook Kim, Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2, Genome Biology, 16, 1, 2015. Crossref
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Ku Chai Siah, Kim Bohkyung, Pham Tho X., Yang Yue, Weller Curtis L., Carr Timothy P., Park Young-Ki, Lee Ji-Young, Hypolipidemic Effect of a Blue-Green Alga (Nostoc commune) Is Attributed to Its Nonlipid Fraction by Decreasing Intestinal Cholesterol Absorption in C57BL/6J Mice, Journal of Medicinal Food, 18, 11, 2015. Crossref
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Seo Young-Kyo, Jeon Tae-Il, Chong Hansook Kim, Biesinger Jacob, Xie Xiaohui, Osborne Timothy F., Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy, Cell Metabolism, 13, 4, 2011. Crossref
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Li Jinmei, Ding Lili, Song Baoliang, Xiao Xu, Qi Meng, Yang Qiaoling, Yang Qiming, Tang Xiaowen, Wang Zhengtao, Yang Li, Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway, European Journal of Pharmacology, 770, 2016. Crossref
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Gåfvels Mats, Olin Maria, Chowdhary Bhanu P., Raudsepp Terje, Andersson Ulla, Persson Bengt, Jansson Monica, Björkhem Ingemar, Eggertsen Gösta, Structure and Chromosomal Assignment of the Sterol 12α-Hydroxylase Gene (CYP8B1) in Human and Mouse: Eukaryotic Cytochrome P-450 Gene Devoid of Introns, Genomics, 56, 2, 1999. Crossref
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Bochar Daniel A., Freisen Jona., Stauffacher Cynthia V., Rodwell Victor W., Biosynthesis of Mevalonic Acid from Acetyl-CoA, in Comprehensive Natural Products Chemistry, 1999. Crossref
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Shin Dong-Ju, Osborne Timothy F., Thyroid Hormone Regulation and Cholesterol Metabolism Are Connected through Sterol Regulatory Element-binding Protein-2 (SREBP-2), Journal of Biological Chemistry, 278, 36, 2003. Crossref
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Yin Liya, Zhang Yanqiao, Hillgartner F. Bradley, Sterol Regulatory Element-binding Protein-1 Interacts with the Nuclear Thyroid Hormone Receptor to Enhance Acetyl-CoA Carboxylase-α Transcription in Hepatocytes, Journal of Biological Chemistry, 277, 22, 2002. Crossref
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Yang Yue, Seo Jeong Min, Nguyen Anthony, Pham Tho X., Park Hea Jin, Park Youngki, Kim Bohkyung, Bruno Richard S., Lee Jiyoung, Astaxanthin-Rich Extract from the Green Alga Haematococcus pluvialis Lowers Plasma Lipid Concentrations and Enhances Antioxidant Defense in Apolipoprotein E Knockout Mice, The Journal of Nutrition, 141, 9, 2011. Crossref
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Rasmussen Heather E., Blobaum Kara R., Park Young-Ki, Ehlers Sarah J., Lu Fan, Lee Ji-Young, Lipid Extract of Nostoc commune var. sphaeroides Kützing, a Blue-Green Alga, Inhibits the Activation of Sterol Regulatory Element Binding Proteins in HepG2 Cells, The Journal of Nutrition, 138, 3, 2008. Crossref
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Peffley Dennis M., Gayen Apurba K., Plant-Derived Monoterpenes Suppress Hamster Kidney Cell 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Synthesis at the Post-Transcriptional Level, The Journal of Nutrition, 133, 1, 2003. Crossref
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Schaal Thomas D., Holmes Michael C., Rebar Edward J., Case Casey C., Novel Approaches to Controlling Transcription, in Genetic Engineering, 2002. Crossref
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Lopez Dayami, McLean Mark P., Sterol Regulatory Element-Binding Protein-1a Binds to cis Elements in the Promoter of the Rat High Density Lipoprotein Receptor SR-BI Gene1, Endocrinology, 140, 12, 1999. Crossref
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Shea-Eaton Wendy K., Trinidad Marie Joy, Lopez Dayami, Nackley Anna, McLean Mark P., Sterol Regulatory Element Binding Protein-1a Regulation of the Steroidogenic Acute Regulatory Protein Gene*, Endocrinology, 142, 4, 2001. Crossref
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Yang Licong, Zhao Yan, Pan Yongfang, Li Dongming, Zheng Guodong, Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice, Nutrition & Metabolism, 16, 1, 2019. Crossref
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Lopez Dayami, Abisambra Socarrás Jose F., Bedi Mohini, Ness Gene C., Activation of the hepatic LDL receptor promoter by thyroid hormone, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1771, 9, 2007. Crossref
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Kervizic Gwenael, Corcos Laurent, Dynamical modeling of the cholesterol regulatory pathway with Boolean networks, BMC Systems Biology, 2, 1, 2008. Crossref
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Devarenne Timothy P., Ghosh Anirban, Chappell Joe, Regulation of Squalene Synthase, a Key Enzyme of Sterol Biosynthesis, in Tobacco, Plant Physiology, 129, 3, 2002. Crossref
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Athanikar J N, Sanchez H B, Osborne T F, Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1, Molecular and Cellular Biology, 17, 9, 1997. Crossref
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Field F. Jeffrey, Born Ella, Murthy Shubha, Mathur Satya N., Gene expression of sterol regulatory element-binding proteins in hamster small intestine, Journal of Lipid Research, 42, 1, 2001. Crossref
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Magaña M M, Lin S S, Dooley K A, Osborne T F, Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins, Journal of Lipid Research, 38, 8, 1997. Crossref
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Osborne Timothy F., Espenshade Peter J., Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been, Genes & Development, 23, 22, 2009. Crossref
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Field F. Jeffrey, Born Ella, Mathur Satya N., Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression, Journal of Lipid Research, 44, 6, 2003. Crossref
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Datta Shrimati, Osborne Timothy F., Activation Domains from Both Monomers Contribute to Transcriptional Stimulation by Sterol Regulatory Element-binding Protein Dimers, Journal of Biological Chemistry, 280, 5, 2005. Crossref
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Magaña Marisa M., Osborne Timothy F., Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter, Journal of Biological Chemistry, 271, 51, 1996. Crossref
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Vallett Shawn Millinder, Sanchez Hugo B., Rosenfeld John M., Osborne Timothy F., A Direct Role for Sterol Regulatory Element Binding Protein in Activation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene , Journal of Biological Chemistry, 271, 21, 1996. Crossref
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Athanikar Jyoti N., Osborne Timothy F., Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein, Proceedings of the National Academy of Sciences, 95, 9, 1998. Crossref
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Field F. Jeffrey, Born Ella, Murthy Shubha, Mathur Satya N., Regulation of Sterol Regulatory Element-binding Proteins in Hamster Intestine by Changes in Cholesterol Flux, Journal of Biological Chemistry, 276, 20, 2001. Crossref
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Nohturfft Axel, Brown Michael S., Goldstein Joseph L., Topology of SREBP Cleavage-activating Protein, a Polytopic Membrane Protein with a Sterol-sensing Domain, Journal of Biological Chemistry, 273, 27, 1998. Crossref
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Seo Young-Kyo, Chong Hansook Kim, Infante Aniello M., Im Seung-Soon, Xie Xiaohui, Osborne Timothy F., Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif, Proceedings of the National Academy of Sciences, 106, 33, 2009. Crossref
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Swinnen Johannes V., Alen Philippe, Heyns Walter, Verhoeven Guido, Identification of Diazepam-binding Inhibitor/Acyl-CoA-binding Protein as a Sterol Regulatory Element-binding Protein-responsive Gene, Journal of Biological Chemistry, 273, 32, 1998. Crossref