Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 2.156 Facteur d'impact sur 5 ans: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i4.30
pages 289-297

The Biology of Mycobacterium Cord Factor and Roles in Pathogen-Host Interaction

Chunmei Li
School of Life Sciences
Qinglin Du
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing, China
Wanyan Deng
Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China
Jianping Xie
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Ecoenvironments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China

RÉSUMÉ

Mycobacterium cord factor was long held as a virulence factor contributing to the pathogenesis of Mycobacterium tuberculosis. Abundant studies have shed light on its unique chemical structures, metabolism, and receptors on macrophages. The mechanisms underlying cord factor virulence remain elusive. This progress is summarized in this paper, especially the receptors of cord factor, such as Toll-like receptors and Mincle. This might facilitate better use of cord factor as an adjuvant for tuberculosis therapy or selection of drug targets involved in its biosynthesis to combat tuberculosis.


Articles with similar content:

Mycobacterium Tuberculosis Proteases and Implications for New Antibiotics Against Tuberculosis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 4
Jianping Xie, Quanju Zhao
Scaffold-Free Spheroids Derived from Stem Cells for Tissue-Engineering Applications
Critical Reviews™ in Biomedical Engineering, Vol.46, 2018, issue 5
Pradnya M. Salve, Kaushik U. Desai, Neha B. Sapkal, Jay R. Dave, Geetanjali B. Tomar
New Insights into the Pathogenesis of Tuberculosis Revealed by Mycobacterium marinum: The Zebrafish Model from the Systems Biology Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 4
Jianping Xie, XieMei Tang, Manmei Hou, Wanyan Deng, Chunmei Li
Regulatory T-Cell Therapy in Transplantation and Severe Autoimmunity
Critical Reviews™ in Immunology, Vol.35, 2015, issue 6
Roberto Spreafico, Maura Rossetti
Therapeutic Opportunities in Colon-Specific Drug-Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 2
Avani Amin, Mayur M. Patel, Tejal Shah