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Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 2.156 Facteur d'impact sur 5 ans: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v13.i24.80
16 pages

Osteoblast Precursors at Different Anatomic Sites

Tilmann Wurtz
Universite Paris 7, Institut Biomedical des Cordeliers - IFR58, INSERM E110, 15-21 rue de l’Ecole de Medecine, 75270 Paris CEDEX 06, France
Ariane Berdal
Universite Paris 7, Institut Biomedical des Cordeliers - IFR58, INSERM E110, 15-21 rue de l’Ecole de Medecine, 75270 Paris CEDEX 06, France

RÉSUMÉ

Skeletal morphology depends on the local regulation of bone formation, both in a quantitative and qualitative sense. The formative cells, osteoblasts, adjust their synthetic activity in response to signals that influence cell differentiation and matrix production. Here, we review data concerning the morphological patterning during bone ontogenesis and its direct cause: osteoblasts at specific anatomic sites. An overview of the possible origins of osteogenic cells is presented, considering bone growth and homeostasis, and discussing the repair process. A testable model is proposed, in which functional differences between osteoblast populations are explained by homeobox-gene regulation. Newly developed markers for osteoblast recruitment and differentiation provide an experimental system to test the impact of homeobox-gene expression on osteoblast differentiation and bone matrix production.


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