Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
Expression of Vascular Endothelial Growth Factor in the Dental Follicle
RÉSUMÉ
Tooth eruption requires the presence of the dental follicle to recruit mononuclear cells, which fuse to form osteoclasts that resorb the alveolar bone such that the tooth can erupt. In the rat first mandibular molar, there is a major burst of osteoclastogenesis at day 3 postnatally and a lesser burst at day 10. Eruption molecules, such as CSF-1, are maximally expressed at day 3 in the dental follicle to promote this maximal osteoclast formation, but by the time of the secondary burst of osteoclastogenesis their expression is dramatically reduced. Because vascular endothelial growth factor (VEGF) can substitute for CSF-1 to promote osteoclastogenesis, we examined its gene expression in vivo in the dental follicle and found that it and its two major isoforms (VEGF 120 and 164) were all maximally expressed at days 9–11, the time of the secondary burst. Treatment of the cells with phorbolmyristate acetate (PMA), a protein kinase C (PKC) activator, enhanced expression of the 2 major VEGF isoforms in the cultured dental follicle cells, whereas adding a specific PKC inhibitor prevented this. Treatment with PMA also increased the protein level of VEGF. Thus, VEGF may be involved in promoting the secondary burst of osteoclastogenesis, and activation of PKC may upregulate its expression.
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CHEN Xue-peng, QIAN Hong, WU June-jie, MA Xian-wei, GU Ze-xu, SUN Hai-yan, DUAN Yin-zhong, JIN Zuo-lin, Expression of vascular endothelial growth factor in cultured human dental follicle cells and its biological roles, Acta Pharmacologica Sinica, 28, 7, 2007. Crossref
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Wise GE, Cellular and molecular basis of tooth eruption, Orthodontics & Craniofacial Research, 12, 2, 2009. Crossref
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Yao Shaomian, Pan Fenghui, Wise Gary E., Chronological gene expression of parathyroid hormone-related protein (PTHrP) in the stellate reticulum of the rat—Implications for tooth eruption, Archives of Oral Biology, 52, 3, 2007. Crossref
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Yao Shaomian, Prpic Veronica, Pan Fenghui, Wise Gary E., TNF-α Upregulates Expression of BMP-2 and BMP-3 Genes in the Rat Dental Follicle—Implications for Tooth Eruption, Connective Tissue Research, 51, 1, 2010. Crossref
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Friedlander L.T., Hussani H., Cullinan M.P., Seymour G.J., De Silva R.K., De Silva H., Cameron C., Rich A.M., VEGF and VEGFR2 in dentigerous cysts associated with impacted third molars, Pathology, 47, 5, 2015. Crossref
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Yao Shaomian, Liu Dawen, Pan Fenghui, Wise Gary E., Effect of vascular endothelial growth factor on RANK gene expression in osteoclast precursors and on osteoclastogenesis, Archives of Oral Biology, 51, 7, 2006. Crossref
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Yao Shaomian, Wise Gary E., In Vivo Expression of Classic PKC Isoforms in the Rat Dental Follicle as Related to Tooth Eruption, Connective Tissue Research, 45, 4-5, 2004. Crossref
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Odgren Paul R., Witwicka Hanna, Reyes-Gutierrez Pablo, The cast of clasts: catabolism and vascular invasion during bone growth, repair, and disease by osteoclasts, chondroclasts, and septoclasts, Connective Tissue Research, 57, 3, 2016. Crossref
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Wise G.E., King G.J., Mechanisms of Tooth Eruption and Orthodontic Tooth Movement, Journal of Dental Research, 87, 5, 2008. Crossref
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Aida M., Irié T., Aida T., Tachikawa T., Expression of Protein Kinases C βI, βII, and VEGF during the Differentiation of Enamel Epithelium in Tooth Development, Journal of Dental Research, 84, 3, 2005. Crossref
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Dai J., Rabie A.B.M., VEGF: an Essential Mediator of Both Angiogenesis and Endochondral Ossification, Journal of Dental Research, 86, 10, 2007. Crossref
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Temple Daniel H., Lieverse Angela R., Bazaliiskii Vladimir I., Faccia Kate, Weber Andrzej, Skeletal and dental maturation relative to tooth formation in prehistoric hunter-gatherers from Cis-Baikal, Siberia, Archaeological Research in Asia, 25, 2021. Crossref
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Xu Jiazhen, Zhang Pei, Chen Yao, Xu Yulan, Luan Pengwei, Zhu Yuying, Zhang Jiange, Sodium tanshinone IIA sulfonate ameliorates cerebral ischemic injury through regulation of angiogenesis, Experimental and Therapeutic Medicine, 22, 4, 2021. Crossref
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Fletcher Anthony M., Bregman Carla L., Woicke Jochen, Salcedo Theodora W., Zidell Robert H., Janke Helen E., Fang Hengsheng, Janusz William J., Schulze Gene E., Mense Mark G., Incisor Degeneration in Rats Induced by Vascular Endothelial Growth Factor/Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibition, Toxicologic Pathology, 38, 2, 2010. Crossref