Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.841 Facteur d'impact sur 5 ans: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v13.i24.120
10 pages

Growth Hormone Receptor and Insulin-like Growth Factor-I Immunoreactivity in Osteoclast-like Cells During Tooth Eruption in the Toothless (Osteopetrotic) Rat Following Treatment with Colony-Stimulating Factor-1

Anne L. Symons
School of Dentistry, University of Queensland, 200 Turbot Street, Brisbane Qld 4000, Australia
Arosha Weerakoon
School of Dentistry, University of Queensland, 200 Turbot Street, Brisbane Qld 4000, Australia
Sandy C. Marks, Jr.
Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA

RÉSUMÉ

In the toothless (tl/tl) osteopetrotic rat, teeth form but fail to erupt. Treatment of tl/tl rats with colony-stimulating factor-1 (CSF-1) activates bone resorption by osteoclasts, permits tooth eruption, and upregulates the immunoreactivity of bone marrow mononuclear cells to growth hormone receptor (GHr) and insulinlike growth factor (IGF)-I. This study examined the distribution of tartrate-resistant acid phosphatase (TRAP) and immunoreactivity for GHr and IGF-I in osteoclast-like cells located on the alveolar bone margin, adjacent to the lower first molar crown, in 14-day-old normal and tl/tl rats, following treatment with CSF-1. Osteoclast-like cells demonstrated a positive reaction for TRAP, GHr, and IGF-I in all groups. However, in tl/tl tissue, osteoclast-like cells were generally negative for GHr. There was no significant difference in the total number of TRAP-, GHr-, and IGF-I-positive osteoclast-like cells on the adjacent bone margin in normal, normal treated with CSF-1, and tl/tl rats. CSF-1 treatment of the tl/tl rat significantly increased the total number of osteoclast-like cells, which were positive for TRAP (p < 0.001), GHr (p < 0.05) and IGF-I (p < 0.01).


Articles with similar content:

The Effects of Colony-Stimulating Factor-1 (CSF-1) on the Development of Osteoclasts and Their Expression of Tartrate-Resistant Acid Phosphatase (TRAP) in Toothless (tl-osteopetrotic) Rats
Critical Reviews™ in Eukaryotic Gene Expression, Vol.13, 2003, issue 2-4
Finn P. Reinholt, Maria Norgard, Goran Andersson, Sandy C. Marks, Jr.
Expression of Vascular Endothelial Growth Factor in the Dental Follicle
Critical Reviews™ in Eukaryotic Gene Expression, Vol.13, 2003, issue 2-4
Gary E. Wise, S. Yao
Changes in Active Lysosomal Cysteine Cathepsins from Thyroid Papillary Carcinoma Tissues with Various Biological Characteristics
International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 1
Tamara M. Myshunina, Olena V. Kalinichenko, Mykola D. Tronko
Method of Intravital Morphometry of the Nucleated Erythrocytes of Fishes
Hydrobiological Journal, Vol.48, 2012, issue 5
V. S. Mukhanov , A.Yu. Andreyeva
Adhesion Molecule Expression in Acute and Chronic Exercise
Critical Reviews™ in Immunology, Vol.20, 2000, issue 3
J. B. Hay, G. Gannon