Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
Progress of FtsZ Inhibitors as Novel Antibiotics Leads
RÉSUMÉ
Bacterial cell division is an attractive target for new antibiotics. FtsZ is a major cytoskeletal protein widespread among archaea and bacteria. FtsZ has a filament-forming GTPase and a structural homologue of eukaryotic tubulin. FtsZ has been validated as a target for antibiotics. This review summarizes the chemical features, binding sites, mechanisms of action, and minimum inhibitory concentration of FtsZ inhibitors.
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Brockway Anthony J., Grove Charles I., Mahoney Maximillian E., Shaw Jared T., Synthesis of the diaryl ether cores common to chrysophaentins A, E, and F, Tetrahedron Letters, 56, 23, 2015. Crossref
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Duggirala Sridevi, Napoleon John Victor, Nankar Rakesh P., Senu Adeeba V., Manheri Muraleedharan K., Doble Mukesh, FtsZ inhibition and redox modulation with one chemical scaffold: Potential use of dihydroquinolines against mycobacteria, European Journal of Medicinal Chemistry, 123, 2016. Crossref
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Veselinović Aleksandar M., Toropov Andrey, Toropova Alla, Stanković-Đorđević Dobrila, Veselinović Jovana B., Design and development of novel antibiotics based on FtsZ inhibition – in silico studies, New Journal of Chemistry, 42, 13, 2018. Crossref
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Hurley Katherine A., Santos Thiago M. A., Nepomuceno Gabriella M., Huynh Valerie, Shaw Jared T., Weibel Douglas B., Targeting the Bacterial Division Protein FtsZ, Journal of Medicinal Chemistry, 59, 15, 2016. Crossref