Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
TCF7L2 rs12255372 (G > T) Polymorphism Contributes to Breast Carcinogenesis: Evidence from a Meta-Analysis
RÉSUMÉ
Studies on the association between the TCF7L2 rs12255372 polymorphism and breast cancer risk have reported conflicting results. To characterize the relationship between this polymorphism and breast cancer risk, we conducted a comprehensive literature search for relevant studies and performed a meta-analysis. A total of four studies including 5280 cases and 6026 controls were eligible for our analysis. Overall, we did find that this polymorphism correlates with breast cancer risk [TT versus GG: odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.02−1.40; GT versus GG: OR = 1.10, 95% CI = 1.01−1.19; T versus G: OR = 1.12, 95% CI = 1.05−1.19]. Furthermore, in the subgroup analysis by ethnicity, we did also find that this polymorphism associated with an increased breast cancer risk in white individuals (T versus G: OR = 1.11, 95% CI = 1.04−1.18). In summary, this meta-analysis suggests that the rs12255372 T allele is a low-penetrant risk factor for breast carcinogenesis. In the future, larger-scale and more well-designed studies based on homogeneous breast cancer patients are needed to validate our findings, especially in Asians.
-
Torres Keila, Labrador Luis, Valderrama Elvis, Chiurillo Miguel Angel, TCF7L2rs7903146 polymorphism is associated with gastric cancer: A case-control study in the Venezuelan population, World Journal of Gastroenterology, 22, 28, 2016. Crossref
-
Zhang Min, Tang Mingshuang, Fang Yanfei, Cui Huijie, Chen Siyu, Li Junlong, Xiong Hongyan, Lu Jiachun, Gu Dongqing, Zhang Ben, Cumulative evidence for relationships between multiple variants in theVTI1AandTCF7L2genes and cancer incidence, International Journal of Cancer, 142, 3, 2018. Crossref