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Computational Thermal Sciences: An International Journal

Publication de 6  numéros par an

ISSN Imprimer: 1940-2503

ISSN En ligne: 1940-2554

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.5 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00017 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.28 SJR: 0.279 SNIP: 0.544 CiteScore™:: 2.5 H-Index: 22

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HYPO- AND HYPERTHERMIA EFFECTS ON MACROSCOPIC FLUID TRANSPORT IN TUMORS

Volume 11, Numéro 1-2, 2019, pp. 119-130
DOI: 10.1615/ComputThermalScien.2018024802
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RÉSUMÉ

Combining the effects of transvascular and interstitial fluid movement with the structural mechanics of a tissue is necessary to properly analyze processes such as nutrient transport in a tumor cell. Furthermore, externally induced heat loads can play a role: for example, cryoablation can be performed by means of hypothermia and hyperthermia can be induced in order to treat some kinds of tumors such as liver tumor. Recently, the study of the effects of hypo- and hyperthermia on fluid flow and mass transport in biological systems by considering the fluid–structure interaction has gained researchers' attention. In this paper, fluid flow in a tumor mass is analyzed at the macroscopic scale by considering the effects of both solid tissue deformation and temperature via hypo- and hyperthermia. Governing equations are averaged over a representative elementary volume of the living tissue, and written by means of the thermo-poroelasticity theory. Darcy's law is used to describe fluid flow through the interstitial space, while transvascular transport is described with a generalized Starling's law. The effects of hypo- and hyperthermia on the living tissue are included with a source term in the tissue momentum equation that considers thermal expansion. This term can be either negative or positive, i.e., hypo- or hyperthermia is herein considered. Governing equations with the appropriate boundary conditions are solved with the finite-element commercial code COMSOL Multiphysics in the steady-state regime. The numerical model is validated with analytical results from previously published results for an isothermal case. Results are presented in terms of pressure, velocity, and temperature fields for various thermal loads and the effects of hypo- and hyperthermia on various physical parameters are analyzed.

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