Publication de 4 numéros par an
ISSN Imprimer: 1947-5764
ISSN En ligne: 1947-5772
Indexed in
The Effect of Cold Atmospheric Plasma Treatment on Cancer Stem Cells
RÉSUMÉ
Intratumoral heterogeneity challenges existing paradigms for anticancer therapy. Accumulating evidence demonstrates that the model of cancer stem cells (CSCs) and the model of clonal evolution mutually contribute to intratumoral heterogeneity, as CSCs themselves undergo clonal evolution. The limitation of conventional anticancer therapies may lead to treatment failure and cancer recurrence, mainly due to drug resistance and self-renewal capacities of CSC. These two factors are responsible for resistance to standard oncology treatments. In this study, we examine cold atmospheric plasma (CAP) treatment of CSC in vitro. We demonstrate that two types of heterogeneous CSC populations derived from a single patient tumor are sensitive to the effects of plasma treatment. Surprisingly, the more aggressive CSC population (C13) was more sensitive to CAP treatment than the less aggressive type (C12).
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Kostyakov D. V., Zinovev E. V., Soloshenko V. V., Zavorotnii O. O., Popov A. A., Asadulaev M. S., Osmanov K. F., Evaluating the effectiveness of combined use of non-thermal atmospheric pressure plasma and frequently-modulated electric field signal in skin wound healing, Innovative medicine of Kuban, 3, 2020. Crossref
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Gjika Eda, Kirschner Megan, Cheng Xiaoqian, Chen Zhitong, Keidar Michael, An Investigation of the Immediate Effect of Cold Atmospheric Plasma on Cancer Cells, 2017 IEEE International Conference on Plasma Science (ICOPS), 2017. Crossref