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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Imprimer: 0278-940X
ISSN En ligne: 1943-619X

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Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2014010490
pages 323-341

Nanoparticle Interface to Biology: Applications in Probing and Modulating Biological Processes

James Chen Yong Kah
National University of Singapore
Eugenia Li Ling Yeo
Nanomedicine and Nanobiology Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore
Wee Ling Koh
Nanomedicine and Nanobiology Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore
Barbara Elodie Ariane Poinard
Department of Biomedical Engineering, University of Paris Descartes, Paris, France
Dawn Jing Hui Neo
Nanomedicine and Nanobiology Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore

RÉSUMÉ

Nanomaterials can be considered as "pseudo" subcellular entities that are similar to endogenous biomolecules because of their size and ability to interact with other biomolecules. The interaction between nanoparticles and biomolecules gives rise to the nano-bio interface between a nanoparticle and its biological environment. This is often defined in terms of the biomolecules that are present on the surface of the nanoparticles. The nano-bio interface alters the surface characteristics and is what the biological system sees and interacts with. The nanoparticle can thus be viewed as a "scaffold" to which molecules are attached. Intelligent design of this nano-bio interface is therefore crucial to the functionality of nanoscale systems in biology. In this review, we discuss the most common nano-bio interfaces formed from molecules including DNA, polymers, proteins, and antibodies, and discuss their applications in probing and modulating biological processes. We focus our discussion on the nano-bio interface formed on gold nanoparticles as our nanoparticle "scaffold" of interest in part because of our research interest as well as their unique physicochemical properties. While not exhaustive, this review provides a good overview of the latest advances in the use of gold nanomaterial interface to probe and modulate biological processes.


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