Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Imprimer: 0278-940X
ISSN En ligne: 1943-619X

Volumes:
Volume 48, 2020 Volume 47, 2019 Volume 46, 2018 Volume 45, 2017 Volume 44, 2016 Volume 43, 2015 Volume 42, 2014 Volume 41, 2013 Volume 40, 2012 Volume 39, 2011 Volume 38, 2010 Volume 37, 2009 Volume 36, 2008 Volume 35, 2007 Volume 34, 2006 Volume 33, 2005 Volume 32, 2004 Volume 31, 2003 Volume 30, 2002 Volume 29, 2001 Volume 28, 2000 Volume 27, 1999 Volume 26, 1998 Volume 25, 1997 Volume 24, 1996 Volume 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v37.i4-5.20
pages 321-353

Stem Cell-Based Models and Therapies for Neurodegenerative Diseases

Shilpa Iyer
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA
Khaled Alsayegh
Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Sheena Abraham
Department of Chemical & Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia,USA
Raj R. Rao
Department of Human and Molecular Genetics, and Department of Chemical & Life Science Engineering, Virginia Commonwealth University, USA

RÉSUMÉ

Multiple neurodegenerative disorders typically result from irrevocable damage and improper functioning of specialized neuronal cells or populations of neuronal cells. These disorders have the potential to contribute to an already overburdened health care system unless the progression of neurodegeneration can be altered. Progress in understanding neurodegenerative cell biology has been hampered by a lack of predictive and, some would claim, relevant cellular models. Additionally, the research needed to develop new drugs and determine methods for repair or replacement of damaged neurons is severely hampered by the lack of an adequate in vitro human neuron cell-based model. In this context, pluripotent stem cells and neural progenitors and their properties—including unlimited proliferation, plasticity to generate other cell types, and a readily available source of cells—pose an excellent alternative to ex vivo primary cultures or established immortalized cell lines in contributing to our understanding of neurodegenerative cell biology and our ability to analyze the therapeutic or cytotoxic effects of chemicals, drugs, and xenobiotics. Many questions that define the underlying "genesis" of the neuronal death in these disorders also remain unanswered, with evidence suggesting a key role for mitochondrial dysfunction. The assessment of stem cells, neural progenitors, and engineered adult cells can provide useful insights into neuronal development and neurodegenerative processes. Finally, the potential for a combination of cell- and gene-based therapeutics for neurodegenerative disorders is also discussed.


Articles with similar content:

Embryonic and Induced Pluripotent Stem Cells as a Model for Liver Disease
Critical Reviews™ in Biomedical Engineering, Vol.37, 2009, issue 4-5
Alejandro Soto-Gutierrez, Masaki Nagaya, Hiroshi Yagi, Ira J. Fox, Edgar Tafaleng, Stephen C. Strom, Marc C. Hansel
Multiscale Modeling of Gastrointestinal Electrophysiology and Experimental Validation
Critical Reviews™ in Biomedical Engineering, Vol.38, 2010, issue 3
Peng Du, Andrew J. Pullan, Greg O'Grady, John B. Davidson, Leo K. Cheng
Tissues Reborn: Fetal Membrane-Derived Matrices and Stem Cells in Orthopedic Regenerative Medicine
Critical Reviews™ in Biomedical Engineering, Vol.42, 2014, issue 3-4
Natasha Topoluk, Jeremy Mercuri, Renae Keeley
The Ethics of Pharming: Engineering Design at the Genetic Level
Ethics in Biology, Engineering and Medicine: An International Journal, Vol.6, 2015, issue 1-2
Abidemi O. Ologunde, Oyinlola O. Adeyanju
Carbon Source Metabolism and Its Regulation in Cancer Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 1
Chengqian Yin, Shuo Qie, Nianli Sang