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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimer: 0893-9675
ISSN En ligne: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2017020855
pages 99-107

Yin Yang I as an Epimodulator of miRNAs in the Metastatic Cascade

Carlo Ruosi
Department of Human Health Federico II University of Naples, Naples, Italy
Gianluca Colella
Department of Human Health Federico II University of Naples, Naples, Italy
Flavio Fazioli
Division of Musculoskeletal Oncology Surgery, National Cancer Institute, Pascale Foundation, Naples, Italy
Roberta Miceli
S.C. Cellular Biology and Biotherapy, National Cancer Institute, Pascale Foundation, Naples, Italy
Michele Gallo
Division of Musculoskeletal Oncology Surgery, National Cancer Institute, Pascale Foundation, Naples, Italy
Mariano Giuseppe Di Salvatore
Division of Musculoskeletal Oncology Surgery, National Cancer Institute, Pascale Foundation, Naples, Italy
Amelia Cimmino
Institute of Genetics and Biophysics–CNR, Naples, Italy
Filomena de Nigris
Department of Biochemistry Biophysics and General Pathology University of Campania Luigi Vanvitelli, Naples, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology College of Science and Technology, Temple University, Philadelphia, Pennsylvania

RÉSUMÉ

Yin Yang 1 (YY1) belongs to the polycomb group (PcG) of proteins that modify chromatin epigenetically during dynamic regulation of their target genes. The predominant feature of YY1 is the zinc finger, an ancient structural motif that mediates protein–protein interactions and is capable of interacting with both DNA and RNA. Evidence reveals that YY1 acts predominantly as an epigenetic modulator, influencing the activity and/or localization of epigenetic modifiers molecules such as DNA methylation transferases, histone deacetylases, or non-coding RNAs. Deregulation of the epigenome is observed frequently in a variety of cancer types and is often correlated directly with advanced metastatic stages and poor prognosis. In this review, we address the current understanding of YY1 as a recruiter of epi-modifier molecules in the mechanism of aberrant regulation of target genes as a part of the metastatic cascade.