Publication de 6 numéros par an
ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X
Indexed in
Use of Vitamin B12 Conjugates to Deliver Protein Drugs by the Oral Route
RÉSUMÉ
The treatment of patients with most peptide and protein pharmaceuticals must currently be performed by injection, with the accompanying disadvantages of patient discomfort, increased medical costs, and reduced patient compliance. It would be much easier and more acceptable if these drugs could be given by the oral route. Unfortunately, this route cannot be used with most proteins and with peptides due to both the degradation of these molecules within the intestine and their poor uptake across the intestinal wall. In this review, an uptake system is described that potentially overcomes both these problems. This system relies upon the natural uptake mechanism for vitamin B12 to cotransport peptides and proteins linked to the vitamin B12 from the intestine to the circulation. In an exciting extension to this technology, it has been found that it is also possible to transport nanoparticles, linked to the vitamin B12, into the circulation. Such nanoparticles can potentially be loaded with peptides or proteins of choice, and so protect these molecules from degradation in the intestine, while simultaneously transporting them into the circulation. These findings are an important step in realizing the possibility of delivering almost all peptides and proteins via the oral route.
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Lee Hye J., Choi Chanmi, Oral Delivery of Macromolecules for the Development of Therapeutic Agents, in Pharmaceutical Sciences Encyclopedia, 2011. Crossref
-
Takada Kanji, Oral Delivery of Hematopoietic Factors, American Journal of Drug Delivery, 4, 2, 2006. Crossref
-
Hwang Seung Rim, Byun Youngro, Advances in oral macromolecular drug delivery, Expert Opinion on Drug Delivery, 11, 12, 2014. Crossref
-
Sonia Thundiparambil Azeez, Sharma Chandra P., Oral insulin delivery – challenges and strategies, in Oral Delivery of Insulin, 2014. Crossref
-
Petrus Amanda K., Fairchild Timothy J., Doyle Robert P., Orale Verabreichung von Protein- und Peptidwirkstoffen entlang der Vitamin-B12-Route, Angewandte Chemie, 121, 6, 2009. Crossref
-
Petrus Amanda K., Fairchild Timothy J., Doyle Robert P., Traveling the Vitamin B12Pathway: Oral Delivery of Protein and Peptide Drugs, Angewandte Chemie International Edition, 48, 6, 2009. Crossref
-
Singh Rajesh, Singh Shailesh, Lillard James W., Past, Present, and Future Technologies for Oral Delivery of Therapeutic Proteins, Journal of Pharmaceutical Sciences, 97, 7, 2008. Crossref
-
Alpers David H., Intrinsic Factor, in Wiley Encyclopedia of Molecular Medicine, 2002. Crossref
-
Fedosov Sergey N., Grissom Charles B., Fedosova Natalya U., Moestrup Søren K., Nexø Ebba, Petersen Torben E., Application of a fluorescent cobalamin analogue for analysis of the binding kinetics, FEBS Journal, 273, 20, 2006. Crossref
-
des Rieux Anne, Fievez Virginie, Garinot Marie, Schneider Yves-Jacques, Préat Véronique, Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach, Journal of Controlled Release, 116, 1, 2006. Crossref
-
He Haibing, Wang Puxiu, Cai Cuifang, Yang Rui, Tang Xing, VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption, International Journal of Pharmaceutics, 493, 1-2, 2015. Crossref
-
Coelho Sílvia Castro, Pereira Maria Carmo, Juzeniene Asta, Juzenas Petras, Coelho Manuel A.N., Supramolecular nanoscale assemblies for cancer diagnosis and therapy, Journal of Controlled Release, 213, 2015. Crossref
-
Zelder Felix, Recent trends in the development of vitamin B12derivatives for medicinal applications, Chemical Communications, 51, 74, 2015. Crossref
-
Bogunia-Kubik Katarzyna, Sugisaka Masanori, From molecular biology to nanotechnology and nanomedicine, Biosystems, 65, 2-3, 2002. Crossref
-
Gomez-Orellana Isabel, Strategies to improve oral drug bioavailability, Expert Opinion on Drug Delivery, 2, 3, 2005. Crossref
-
Zelikin Alexander N., Ehrhardt Carsten, Healy Anne Marie, Materials and methods for delivery of biological drugs, Nature Chemistry, 8, 11, 2016. Crossref
-
Mosayebi Jalal, Kiyasatfar Mehdi, Laurent Sophie, Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications, Advanced Healthcare Materials, 6, 23, 2017. Crossref
-
TUMA PAMELA L., HUBBARD ANN L., Transcytosis: Crossing Cellular Barriers, Physiological Reviews, 83, 3, 2003. Crossref
-
Goldberg Michael, Gomez-Orellana Isabel, Challenges for the oral delivery of macromolecules, Nature Reviews Drug Discovery, 2, 4, 2003. Crossref
-
YAMAMOTO Akira, Improvement of Transmucosal Absorption of Biologically Active Peptide Drugs, YAKUGAKU ZASSHI, 121, 12, 2001. Crossref
-
Brayden David J, Maher Sam, Oral absorption enhancement: taking the next steps in therapeutic delivery, Therapeutic Delivery, 1, 1, 2010. Crossref
-
Russell-Jones Greg, Advances and Challenges in Oral Delivery of Macromolecules, 2016. Crossref
-
Russell-Jones Greg, Advances and challenges in oral delivery of macromolecules, in Advances and Challenges in Oral Delivery of Macromolecules, 2016. Crossref
-
Pieńko Tomasz, Wierzba Aleksandra J., Wojciechowska Monika, Gryko Dorota, Trylska Joanna, Conformational Dynamics of Cyanocobalamin and Its Conjugates with Peptide Nucleic Acids, The Journal of Physical Chemistry B, 121, 14, 2017. Crossref
-
Kaklotar Dhansukh, Agrawal Poornima, Abdulla Allabakshi, Singh Rahul P, Mehata Abhishesh K, Singh Sanjay, Mishra Brahmeshwar, Pandey Bajarangprasad L, Trigunayat Anshuman, Muthu Madaswamy S, Transition from passive to active targeting of oral insulin nanomedicines: enhancement in bioavailability and glycemic control in diabetes, Nanomedicine, 11, 11, 2016. Crossref
-
Rajeshwari K., Vasantha P., Shekhar B., Anantha Lakshmi P. V., Metformin-Derived Water-Soluble Cobalt Complexes: Thermal, Spectroscopic, DNA Interaction, and Molecular Docking Studies, Applied Biochemistry and Biotechnology, 194, 6, 2022. Crossref
-
Vlahov Iontcho R., Kleindl Paul J., You Fei, Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors, in Drug Delivery in Oncology, 2011. Crossref