Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2017016936
pages 149-183

Supramolecular Delivery Systems for Non-Platinum Metal-Based Anticancer Drugs

Paola Ringhieri
Department of Pharmacy, Interuniversity Research Centre on Bioactive Peptides (CIRPeB), Member of CIRCMSB, University of Naples "Federico II," via Mezzocannone 16, 80134 Napoli, Italy
Giancarlo Morelli
Department of Pharmacy, Interuniversity Research Centre on Bioactive Peptides (CIRPeB), Member of CIRCMSB, University of Naples "Federico II," via Mezzocannone 16, 80134 Napoli, Italy
Antonella Accardo
Department of Pharmacy, Interuniversity Research Centre on Bioactive Peptides (CIRPeB), Member of CIRCMSB, University of Naples "Federico II," via Mezzocannone 16, 80134 Napoli, Italy

RÉSUMÉ

Stimulated by the enormous success of the inorganic complex cisplatin in tumor treatment, interest in metal complexes has recently grown. Within cells, metal complexes can participate in reactions that are not possible with conventional organic substances, and most of them have promising efficacy as anticancer drugs. However, to be effective in vivo metal complexes need adequate delivery systems able to increase their water solubility, the in vivo bioavailability, and the safe delivery to target organs. The present review reports on the state of the art of these new, nonplatinum, anticancer metallodrugs delivered by nanosized vehicles. The development of complexes of ruthenium, gold, cobalt, copper, gallium, and others that show promising antitumor efficacy is reported, and we emphasize the different approaches in the individuation of the most appropriate delivery system for each of them.


Articles with similar content:

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 6
Eliahu Heldman, Kristin Loomis, Brandon Smith, Anu Puri, Jae-Ho Lee, Amichai Yavlovich, Robert Blumenthal
Recent Developments in the Use of Bioadhesive Systems for Delivery of Drugs to the Oral Cavity
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 4
John D. Smart
Current Applications of Polysaccharides in Colon Targeting
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.13, 1996, issue 3-4
Helle Brondsted, Lars Hovgaard
Dry Powder Nasal Vaccines as an Alternative to Needle-Based Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 1
Robert J. Garmise, Anthony J. Hickey
Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu