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Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v25.i5.20
pages 449-484

Sublingual Drug Delivery

Tarun Goswami
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211
Bhaskara R. Jasti
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211
Xiaoling Li
Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211

RÉSUMÉ

The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation. Attempts have been made to deliver various pharmacologically active agents, such as cardiovascular drugs, analgesics, and peptides, across the sublingual mucosa. In this review, the anatomical structure, blood supply, biochemical composition, transport pathways, permeation enhancement strategies, in vitro / in vivo models, and clinical investigations for the sublingual route of drug delivery is discussed.


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