Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

Volume 37, 2020 Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v20.i1.10
62 pages

Mitochondrial-Targeted Drug and DNA Delivery

Volkmar Weissig
Northeastern University, Bouve College of Health Sciences, School of Pharmacy, Department of Pharmaceutical Sciences, 360 Huntington Avenue, Mugar 211, Boston MA 02115, USA


The field of mitochondrial research is currently among the fastest growing disciplines in biomedicine. Approximately 12,000 articles on mitochondria have been published since the beginning of the new millennium. What brings mitochondria into the limelight of the scientific community? Since the end of the 1980s, a series of key discoveries has been made that have rekindled the scientific interest in this long-known cell organelle. It has become increasingly evident that mitochondrial dysfunction contributes to a variety of human disorders, ranging from neurodegenerative and neuromuscular diseases, obesity, and diabetes to ischemia-reperfusion injury and cancer. Moreover, since the middle of the 1990s, mitochondria, the “power houses” of the cell, have also become accepted as the cells’ “arsenal,” reflecting their increasingly acknowledged key role during apoptosis. Based on these recent developments in mitochondrial research, increased pharmacological and pharmaceutical efforts have lead to the emergence of “mitochondrial medicine” as a new field of biomedical research. Targeting of biologically active molecules to mitochondria in living cells will open avenues for manipulating mitochondrial functions, which may result in the selective protection, repair, or eradication of cells. This review gives a comprehensive overview of current strategies of mitochondrial targeting and their possible therapeutic applications.

Articles with similar content:

Magnetotherapy: Historical Background With a Stimulating Future
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.16, 2004, issue 2
Michael I. Weintraub
MHC Genes Linked to Autoimmune Disease
Critical Reviews™ in Immunology, Vol.35, 2015, issue 3
Philip Deitiker, M. Zouhair Atassi
The Role of the Apoptotic Machinery in Ionizing Radiation-Induced Carcinogenesis
Critical Reviews™ in Oncogenesis, Vol.21, 2016, issue 3-4
Elizabeth K. Balcer-Kubiczek
Neurosteroids and Ischemic Stroke: Progesterone a Promising Agent in Reducing the Brain Injury in Ischemic Stroke
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 3
Syed Suhail Andrabi, Suhel Parvez, Heena Tabassum
Stem Cell-Based Models and Therapies for Neurodegenerative Diseases
Critical Reviews™ in Biomedical Engineering, Vol.37, 2009, issue 4-5
Khaled Alsayegh, Sheena Abraham, Raj R. Rao, Shilpa Iyer