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Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v14.i3.30
45 pages

Targeted Delivery of Peptides, Proteins, and Genes by Receptor-Mediated Endocytosis

Yukio Kato
Faculty of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan
Yuichi Sugiyama
Faculty of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan

RÉSUMÉ

Receptor-mediated endocytosis (RME) is one type of delivery system by which therapeutic agents can be specifically transported to their target. Although many successful studies have been performed at a preclinical level, its clinical application is restricted by a number of factors, including the low targeting efficiency that stems from the characteristics of RME. One important approach to overcome this is to improve the drug delivery system by a series of chemical modifications and evaluate the drug targeting efficiency from a kinetic point of view.


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