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Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v13.i3-4.20
pages 225-256

The Role of Scanning Probe Microscopy in Drug Delivery Research

Kevin M. Shakesheff
EPSRC Advanced Fellow. Tissue Engineering Group School of Pharmaceutical Sciences The University of Nottingham Nottingham NG7 2RD United Kingdom
Martyn C. Davies
Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Science, The University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom
Clive Roberts
School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
Saul J. B. Tendler
Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Science, The University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom
Philip M. Williams
Laboratory of Biophysics and Surface Analysis, Department of Pharmaceutical Science, The University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom

RÉSUMÉ

The success of a drug delivery system is often dependent on the surface properties of the device. These surface properties will determine the complex dynamic interfacial events that occur when the system is introduced into the aqueous environment of a patient. Development of the scanning probe microscopes has provided a number of very powerful new surface analytical techniques that are making a significant contribution to the characterization of drug delivery systems and the interfacial processes that occur when such systems are exposed to aqueous living environments. In this review, we describe the design and attributes of these instruments and discuss the impact of the techniques on a wide range of drug delivery research. The scanning probe microscopes are providing new insights into important problems concerning drug delivery, including the molecular structure of polymeric biomaterial surfaces, the conformation of target biomolecules, the influence of morphology on biodegradation, the adsorption of proteins to synthetic surfaces, and the structure and interactions of colloidal particles. As the whole field of scanning probe microscopy continues to advance, drug delivery research is set to benefit, in the final section of the review, the future potential derived from the ability to characterize new surface properties under aqueous conditions is discussed.


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