Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2016014850
pages 107-158

Chitosan Nanoparticles Prepared by Ionotropic Gelation: An Overview of Recent Advances

Kashappa Goud Desai
Biopharmaceutical Product Sciences, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406


The objective of this review is to summarize recent advances in chitosan nanoparticles prepared by ionotropic gelation. Significant progress has occurred in this area since the method was first reported. The gelation technique has been improved through a number of creative methodological modifications. Ionotropic gelation via electrospraying and spinning disc processing produces nanoparticles with a more uniform size distribution. Large-scale manufacturing of the nanoparticles can be achieved with the latter approach. Hydrophobic and hydrophilic drugs can be simultaneously encapsulated with high efficiency by emulsification followed by ionic gelation. The turbulent mixing approach facilitates nanoparticle formation at a relatively high polymer concentration (5 mg/mL). The technique can be easily tuned to achieve the desired polymer/surface modifications (e.g., blending, coating, and surface conjugation). Using factorial-design-based approaches, optimal conditions for nanoparticle formation can be determined with a minimum number of experiments. New insights have been gained into the mechanism of chitosan−tripolyphosphate nanoparticle formation. Chitosan nanoparticles prepared by ionotropic gelation tend to aggregate/agglomerate in unfavorable environments. Factors influencing this phenomenon and strategies that can be adopted to minimize the instability are discussed. Ionically cross-linked nanoparticles based on native chitosan and modified chitosan have shown excellent efficacy for controlled and targeted drug-delivery applications.

Articles with similar content:

Emerging Potential of Nanosuspension-Enabled Drug Delivery: An Overview
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 6
Vivek Ranjan Sinha, Silki
International Journal of Energetic Materials and Chemical Propulsion, Vol.18, 2019, issue 4
Marc Comet, Florent Pessina, Emeline Lobry, Volker Deckert, Tanja Deckert-Gaudig, Vincent Pichot, Jean-Edouard Berthe, Denis Spitzer
Polymeric and Lipid-Based Materials for Topical Nanoparticle Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 5
R. Jayachandra Babu, Kasturi R. Pawar
International Journal of Energetic Materials and Chemical Propulsion, Vol.5, 2002, issue 1-6
M. P. Prigozhina, L. G. Komarova, V. A. Tartakovsky, S. A. Shevelev, A. L. Rusanov, M. D. Dutov
Microsponges: A Pioneering Tool for Biomedical Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 1
Amit Verma, Ankit Jain, Pooja Hurkat, Amrita Kumari, Sanjay Kumar Jain