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Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v15.i5.30
43 pages

Hyaluronate Derivatives in Drug Delivery

Koen P. Vercruysse
Department of Medicinal Chemistry, 30 South 2000 East, Room 201, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112-5820, U.S.A.
Glenn D. Prestwich
Department of Medicinal Chemistry, 30 South 2000 East, Room 201, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112-5820, U.S.A.

RÉSUMÉ

Hyaluronan (HA), an abundant nonsulfated glycosaminoglycan component of synovial fluid and the extracellular matrix, is an attractive building block for new biocompatible and biodegradable polymers that have applications in drug delivery, tissue engineering, and viscosupplementation. This review consists of three subtopics: (i) chemical modification of HA; (ii) physicochemical and biochemical characterization of HA derivatives; and (iii) in vitro and in vivo bioevaluation studies. Important new products have already reached the marketplace, and the approval and introduction of a variety of new medical applications of HA-based biomaterials can be anticipated in the next decade.


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