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Critical Reviews™ in Therapeutic Drug Carrier Systems
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ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2013005964
pages 217-256

Drug Carrier Systems for Solubility Enhancement of BCS Class II Drugs: A Critical Review

Sumit Kumar
Nanomedicine Research Lab, Department of Pharmaceutics, ISF College of Pharmacy, Moga
Deepak Bhargava
Department of Quality Assurance, ISF College of Pharmacy, Moga
Arti Thakkar
Department of Quality Assurance, ISF College of Pharmacy, Moga
Saahil Arora
Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India 09501223252(M)

RÉSUMÉ

Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. In this literature review, novel formulation options, particularly for class II drugs designed for applications such as micronization, self-emulsification, cyclodextrin complexation, co-crystallisation, super critical fluid technology, solubilisation by change in pH, salt formation, co-solvents, melt granulation, and solid dispersion, liposomal/niosomal formulations, are discussed in detail to introduce biopharmaceutical challenges and recent approaches to facilitate more efficient drug formulation and development.


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