Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v29.i2.20
pages 149-182

Drug-Loaded PLGA Nanoparticles for Oral Administration: Fundamental Issues and Challenges Ahead

Gaurav Kumar
Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai-410210, India
Nusrat Shafiq
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
Samir Malhotra
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India

RÉSUMÉ

Drug-loaded polylactide-co-glycolide (PLGA) nanoparticles have been extensively studied and have a practical impact on drug delivery. Many PLGA-based nanoformulations have reached different stages of preclinical development; however, they present distinct challenges for researchers. This review discusses some of the challenges and issues involved in selecting drug and polymer combinations for encapsulation, aggregation of nanoparticles during characterization in in vitro studies, sterilization, and long-term stability of drug-loaded nanoparticles. We include recommendations to overcome these challenges.


Articles with similar content:

Lipid Nanocarriers: Influence of Lipids on Product Development and Pharmacokinetics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 4
Lav Keshri, Mayank Shah, Kamla Pathak
Engineered PLGA Nanoparticles: An Emerging Delivery Tool in Cancer Therapeutics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 1
Amit K. Jain, Manasmita Das, Nitin K. Swarnakar, Sanyog Jain
Functional Polymeric Nanoparticles: An Efficient and Promising Tool for Active Delivery of Bioactives
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 4
Senthilkumar Murugesan, Tathagata Dutta, Abhay Asthana, Manoj Tare, Surbhi Saraf, Narendra Kumar Jain, Vijayaraj Rajkumar, Manoj Nahar, Dinesh Mishra
Polymeric Immunonanoparticles Mediated Cancer Therapy: Versatile Nanocarriers for Cell-Specific Cargo Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.35, 2018, issue 1
Niyati S. Acharya, Namdev L. Dhas, Ritu R. Kudarha, Sanjeev R. Acharya
The Role of Surface Functionalization in the Design of PLGA Micro- and Nanoparticles
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 1
Michael Wirth, Vera Kerleta, Christian Fillafer, Franz Gabor, Gerda Ratzinger