Publication de 6 numéros par an
ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X
Indexed in
Ligand-Appended BBB-Targeted Nanocarriers (LABTNs)
RÉSUMÉ
Delivering therapeutics across the blood brain barrier (BBB) remains the rate-limiting step in brain medicine research. Three main categories of endogenous transportation at BBB that can be used for targeting brain are carrier-mediated transport, active efflux transport, and receptor-mediated transport. Various approaches using nanocarriers such as liposomes, niosomes, micelles, and nanoparticles with manifested surface modifications using either covalent or noncovalent methods to append suitable ligands are being intensively explored to achieve drug delivery to the brain. Harvested ligands include peptide, glutathione, transferrin, and transferrin antibody, lectins, lactic acid, cholera toxin B, etc. In this review, we present recent insights into the development of safe and efficient brain drug delivery as well as recent advances in BBB targeting tactics including antibody-directed enzyme prodrug therapy, a biotin-avidin conjugated system, and chimeric peptides. This review serves as an excellent source of knowledge for budding brain researchers.
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Rip Jaap, Liposome technologies and drug delivery to the CNS, Drug Discovery Today: Technologies, 20, 2016. Crossref
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Jain Ankit, Jain Sanjay K., In vitro release kinetics model fitting of liposomes: An insight, Chemistry and Physics of Lipids, 201, 2016. Crossref
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He Chunsheng, Cai Ping, Li Jason, Zhang Tian, Lin Lucy, Abbasi Azhar Z., Henderson Jeffrey T., Rauth Andrew Michael, Wu Xiao Yu, Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer, Journal of Controlled Release, 246, 2017. Crossref
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Jain Ankit, Tiwari Ankita, Verma Amit, Jain Sanjay K., Ultrasound-based triggered drug delivery to tumors, Drug Delivery and Translational Research, 8, 1, 2018. Crossref
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Dan Nily, Core–shell drug carriers: liposomes, polymersomes, and niosomes, in Nanostructures for Drug Delivery, 2017. Crossref
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Lembo David, Donalisio Manuela, Civra Andrea, Argenziano Monica, Cavalli Roberta, Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections, Expert Opinion on Drug Delivery, 15, 1, 2018. Crossref
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Wang Xinyi, Qi Bowen, Su Huifang, Li Jianbo, Sun Xun, He Qin, Fu Yao, Zhang Zhirong, Pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter for brain-specific drug delivery, Journal of Controlled Release, 254, 2017. Crossref
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Jain Ankit, Jain Sanjay K., Application Potential of Engineered Liposomes in Tumor Targeting, in Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics, 2017. Crossref
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Antimisiaris Sophia, Mourtas Spyridon, Papadia Konstantina, Brain targeting with lipidic nanocarriers, in Design of Nanostructures for Versatile Therapeutic Applications, 2018. Crossref
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Dan Nily, Vesicle-based drug carriers, in Design and Development of New Nanocarriers, 2018. Crossref
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Patra Jayanta Kumar, Das Gitishree, Fraceto Leonardo Fernandes, Campos Estefania Vangelie Ramos, Rodriguez-Torres Maria del Pilar, Acosta-Torres Laura Susana, Diaz-Torres Luis Armando, Grillo Renato, Swamy Mallappa Kumara, Sharma Shivesh, Habtemariam Solomon, Shin Han-Seung, Nano based drug delivery systems: recent developments and future prospects, Journal of Nanobiotechnology, 16, 1, 2018. Crossref
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Agrawal Mukta, Saraf Swarnlata, Saraf Shailendra, Antimisiaris Sophia G., Hamano Nobuhito, Li Shyh-Dar, Chougule Mahavir, Shoyele Sunday A., Gupta Umesh, Ajazuddin , Alexander Amit, Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region, Expert Opinion on Drug Delivery, 15, 6, 2018. Crossref
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Vaillard Victoria A., Menegon Malen, Neuman Nicolás I., Vaillard Santiago E., mPEG-NHS carbonates: Effect of alkyl spacers on the reactivity: Kinetic and mechanistic insights, Journal of Applied Polymer Science, 136, 5, 2019. Crossref
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Verma Amit, Tiwari Ankita, Panda Pritish Kumar, Saraf Shivani, Jain Ankit, Raikwar Sarjana, Bidla Pooja, Jain Sanjay K., Liposomes for Advanced Drug Delivery, in Advanced Biopolymeric Systems for Drug Delivery, 2020. Crossref
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Food Application and Processing: Nanotechniques and Bioactive Delivery Systems, in Nano‐Technological Intervention in Agricultural Productivity, 2021. Crossref
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Kothale Dhalendra, Verma Utsav, Dewangan Nagesh, Jana Partha, Jain Ankit, Jain Dharmendra, Alginate as Promising Natural Polymer for Pharmaceutical, Food, and Biomedical Applications, Current Drug Delivery, 17, 9, 2020. Crossref
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Saraf Shivani, Jain Ankit, Tiwari Ankita, Verma Amit, Jain Sanjay K., Engineered liposomes bearing camptothecin analogue for tumour targeting: in vitro and ex-vivo studies, Journal of Liposome Research, 31, 4, 2021. Crossref
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Mutingwende Fadzai P., Kondiah Pierre P. D., Ubanako Philemon, Marimuthu Thashree, Choonara Yahya E., Advances in Nano-Enabled Platforms for the Treatment of Depression, Polymers, 13, 9, 2021. Crossref
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Najmi Asim, Wang Shenggang, Huang Yue, Seefeldt Teresa, Alqahtani Yahya, Guan Xiangming, 2-(2-Cholesteroxyethoxyl)ethyl 3′-S-glutathionylpropionate and its self-assembled micelles for brain delivery: Design, synthesis and evaluation, International Journal of Pharmaceutics, 600, 2021. Crossref
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Raikwar Sarjana, Jain Ankit, Saraf Shivani, Tiwari Ankita, Panda Pritish Kumar, Jain Sanjay K., Environmental stimuli-sensitive chitosan nanocarriers in therapeutics, in Chitosan in Biomedical Applications, 2022. Crossref
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Kesharwani Payal, Prajapati Shiv Kumar, Jain Ankit, Mody Nishi, Sharma Swapnil, A glimpse of biomedical application potential of biodegradable polymers for anticancer drug delivery, in Polymeric Biomaterials for Healthcare Applications, 2022. Crossref
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Banerjee Pallabi, Qamar Imteyaz, Nanobiomaterials in biomedicine: Designing approaches and critical concepts, in Nanobioanalytical Approaches to Medical Diagnostics, 2022. Crossref
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Dighe Pearl, Biomedical applications of nanocarriers in brain tumor targeting, in Nanocarriers for Drug-Targeting Brain Tumors, 2022. Crossref
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Raikwar Sarjana, Panda Pritish Kumar, Das Bidla Pooja, Saraf Shivani, Jain Ankit, Jain Sanjay K., Liposomal Delivery System, in Nanotechnology for Biomedical Applications, 2022. Crossref
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Shamshiripour Parisa, Hajiahmadi Fahimeh, Lotfi Shahla, Esmaeili Niloofar Robab, Zare Amir, Akbarpour Mahzad, Ahmadvand Davoud, Next-Generation Anti-Angiogenic Therapies as a Future Prospect for Glioma Immunotherapy; From Bench to Bedside, Frontiers in Immunology, 13, 2022. Crossref
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Bashraheel Sara S, Domling Alexander, Goda Sayed K, Update on targeted cancer therapies, single or in combination, and their fine tuning for precision medicine, Biomedicine & Pharmacotherapy, 125, 2020. Crossref
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Wang Yinan, Su Yanan, Yang Yunqiao, Jin Huan, Wu Moli, Wang Qian, Sun Pengyuan, Zhang Jianbin, Yang Xiaobo, Shu Xiaohong, Increased brain uptake of pterostilbene loaded folate modified micellar delivery system, Drug Delivery, 29, 1, 2022. Crossref
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Najmi Asim, Wang Shenggang, Huang Yue, Seefeldt Teresa, Alqahtani Yahya, Guan Xiangming, 2-(2-Cholesteroxyethoxyl)ethyl-3′-S-glutathionylpropionate (COXP) for brain-targeting liposomes, Journal of Drug Delivery Science and Technology, 75, 2022. Crossref