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Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v26.i2.20
pages 157-205

Role of Block Copolymer Nanoconstructs in Cancer Therapy

K. K. Upadhyay
Université de Bordeaux, ENSCPB; 2CNRS, Laboratoire de Chimie des Polymères Organiques, France; and 3Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The Maharaja Sayajirao University of Baroda, India
H. G. Agrawal
3Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The Maharaja Sayajirao University of Baroda, Vadodara-390001, Gujarat state, India
C. Upadhyay
3Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The Maharaja Sayajirao University of Baroda, Vadodara-390001, Gujarat state, India
C. Schatz
Université de Bordeaux, ENSCPB; CNRS, Laboratoire de Chimie des Polymères Organiques, UMR5629, Pessac, France
J. F. Le Meins
Université de Bordeaux, ENSCPB; CNRS, Laboratoire de Chimie des Polymères Organiques, UMR5629, Pessac, France
Ambikanandan Misra
Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Post Box No. 51, Kalabhavan, Vadodara 390001 Gujarat, India
Sebastian Lecommandoux
Université de Bordeaux, ENSCPB; CNRS, Laboratoire de Chimie des Polymères Organiques, UMR5629, Pessac, France

RÉSUMÉ

Drug, gene, and protein delivery is a very challenging and exciting area in nanobiotechnology where block copolymers are increasingly considered especially as carriers for pharmacotherapy of various cancers. Cancer chemotherapy is particularly challenging because of nonselective distribution of drugs, associated severe toxicity, multidrug resistance, and chronic treatments influencing the quality-adjusted life of patients. These limitations lead to incomplete cure and render many drugs ineffective in treating cancers. Liposomes are currently more advanced in clinical trials and industrial developments but they lack stability and pose difficulties in functionalizing liposomes. More recently, various types of polymer-based nanoconstructs have been designed and synthesized, and are being investigated for the cancer chemotherapy applications. This review discusses the most significant and recent developments on specific self-assembled block copolymers as a carrier system such as micelles and vesicles, which can be successfully used to enhance the solubility of hydrophobic drugs, helpful in targeting selective sites in the body, delivering active molecules in a control manner, and reducing the side effects in the treatment of cancer.


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