Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Immunology
Facteur d'impact: 1.404 Facteur d'impact sur 5 ans: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v30.i6.40
pages 547-557

Role of the Glucocorticoid-Induced TNFR-Related Protein (GITR)-GITR Ligand Pathway in Innate and Adaptive Immunity

Miyuki Azuma
Department of Molecular Immunology, Tokyo Medical and Dental Univerisity

RÉSUMÉ

Glucocorticoid-induced TNF receptor-related protein (GITR) is expressed in regulatory T cells at high levels, but is also inducible in conventional effector T cells after activation. Initial studies using an agonistic anti- GITR mAb mislead this line of research with respect to the contribution of GITR stimulation on the function of regulatory T cells. In fact, GITR acts as a costimulatory receptor for both effector and regulatory T cells by enhancing effector and regulatory functions, respectively. Unlike other costimulatory ligands, GITR ligand (GITRL) expression on mature myeloid dendritic cells (DCs) is extremely limited and the GITR-GITRL pathway does not contribute markedly to direct interactions with T cells and antigen-presenting cells in the secondary lymphoid tissues. Rather, GITRL is constitutively expressed on parenchymal tissue cells and interacts with GITR expressed on tissue-infiltrating macrophages and DCs, or effector and regulatory T cells. Interactions with GITR and GITRL at local inflammatory sites induce site-specific production of cytokines and chemokines, resulting in control activation of tissue-infiltrating effector or regulatory cells and their migration. This review summarizes recent reports on the GITR-GITRL pathway, which controls both innate and adaptive immune responses.


Articles with similar content:

Integrin Function in T-Cell Homing to Lymphoid and Nonlymphoid Sites: Getting There and Staying There
Critical Reviews™ in Immunology, Vol.29, 2009, issue 2
Christopher C. DeNucci, Jason S. Mitchell, Yoji Shimizu
Inhibitory Receptor-Mediated Regulation of Natural Killer Cells
Critical Reviews™ in Immunology, Vol.34, 2014, issue 6
Beena Jeevan-Raj , Camille Grandclement, Werner Held, Elisenda Alari-Pahissa
MHC Transfer from APC to T Cells Following Antigen Recognition
Critical Reviews™ in Immunology, Vol.26, 2006, issue 1
Scott A. Wetzel, David C. Parker
Structure and Function of the CD7 Molecule
Critical Reviews™ in Immunology, Vol.19, 1999, issue 4
Russell E. Kaufman, Barton F. Haynes, Gregory D. Sempowski, David M. Lee
Expression of T Lymphocyte Adhesion Molecules: Regulation During Antigen-Induced T Cell Activation and Differentiation
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
Morris O. Dailey