Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Proteoglycan-Induced Arthritis: Immune Regulation, Cellular Mechanisms, and Genetics
RÉSUMÉ
Rheumatoid arthritis is probably the least understood systemic autoimmune disease, and it affects approximately 1% of the human population. Several lines of evidence indicate that the effector mechanism, which initially attacks small joints, is T-cell driven. As a result, an aggressive synovial pannus develops, which destroys articular cartilage and bone, leading to massive ankylosis and deformities of peripheral joints. The disease has a progressive character, with the involvement of more and more joints. Although the target organ is the synovial joint, there is no clear evidence that any macromolecule of cartilaginous tissues, bone, or synovium, could be a preferential autoantigen. There are numerous rodent models that simulate some or many of the clinical, immunological, or histopathological features of the disease. Recently, it has become a strong working hypothesis that MHC and non-MHC genetic components share loci that are common in various autoimmune diseases, and in corresponding animal models. The most relevant animal models of rheumatoid arthritis appear to be those induced by cartilage matrix components such as type II collagen or proteoglycan aggrecan. This review summarizes our current knowledge of cartilage proteoglycan (aggrecan)-induced arthritis in mice.
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Boldizsar Ferenc, Tarjanyi Oktavia, Nemeth Peter, Mikecz Katalin, Glant Tibor T., Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice, International Immunology, 21, 5, 2009. Crossref
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Szántó Sándor, Bárdos Tamás, Szabó Zoltán, David Chella S., Buzás Edit I., Mikecz Katalin, Glant Tibor T., Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background, Arthritis & Rheumatism, 50, 6, 2004. Crossref
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Adarichev Vyacheslav A., Glant Tibor T., Experimental spondyloarthropathies: Animal models of ankylosing spondylitis, Current Rheumatology Reports, 8, 4, 2006. Crossref
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Hanyecz Anita, Berlo Suzanne E., Szántó Sándor, Broeren Chris P. M., Mikecz Katalin, Glant Tibor T., Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype, Arthritis & Rheumatism, 50, 5, 2004. Crossref
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Hamel Keith M., Cao Yanxia, Wang Yumei, Rodeghero Rachel, Kobezda Tamas, Chen Lieping, Finnegan Alison, B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis, European Journal of Immunology, 40, 11, 2010. Crossref
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Gál István, Bajnok Éva, Szántó Sándor, Sarraj Bara, Glant Tibor T., Mikecz Katalin, Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis, Arthritis & Rheumatism, 52, 10, 2005. Crossref
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Szántó Sándor, Bárdos Tamás, Gál István, Glant Tibor T., Mikecz Katalin, Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice, Arthritis & Rheumatism, 50, 9, 2004. Crossref
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Roord Sarah T. A., de Jager Wilco, Boon Louis, Wulffraat Nico, Martens Anton, Prakken Berent, van Wijk Femke, Autologous bone marrow transplantation in autoimmune arthritis restores immune homeostasis through CD4+CD25+Foxp3+ regulatory T cells, Blood, 111, 10, 2008. Crossref
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Berlo Suzanne E., Guichelaar Teun, ten Brink Corlinda B., van Kooten Peter J., Hauet-Broeren Femke, Ludanyi Katalin, van Eden Willem, Broeren Chris P., Glant Tibor T., Increased arthritis susceptibility in cartilage proteoglycan–specific T cell receptor–transgenic mice, Arthritis & Rheumatism, 54, 8, 2006. Crossref
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Szabó Zoltán, Szántó Sándor, Végvári Anikó, Szekanecz Zoltán, Mikecz Katalin, Glant Tibor T., Genetic control of experimental spondylarthropathy, Arthritis & Rheumatism, 52, 8, 2005. Crossref
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Wieten Lotte, van der Zee Ruurd, Spiering Rachel, Wagenaar-Hilbers Josée, van Kooten Peter, Broere Femke, van Eden Willem, A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis, Arthritis & Rheumatism, 62, 4, 2010. Crossref
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Asquith Darren L., Miller Ashley M., McInnes Iain B., Liew Foo Y., Animal models of rheumatoid arthritis, European Journal of Immunology, 39, 8, 2009. Crossref
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Kaplan Charles D., Cao Yancia, Verbeek J. Sjef, Tunyogi-Csapo Miklos, Finnegan Alison, Development of proteoglycan-induced arthritis is critically dependent on Fcγ receptor type III expression, Arthritis & Rheumatism, 52, 5, 2005. Crossref
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Bevaart Lisette, Vervoordeldonk Margriet J., Tak Paul P., Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?, Arthritis & Rheumatism, 62, 8, 2010. Crossref
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Hutás Gábor, Bajnok Éva, Gál István, Finnegan Alison, Glant Tibor T., Mikecz Katalin, CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis, Blood, 112, 13, 2008. Crossref
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Goronzy Jorg J., Shao Lan, Weyand Cornelia M., Immune Aging and Rheumatoid Arthritis, Rheumatic Disease Clinics of North America, 36, 2, 2010. Crossref
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Berlo Suzanne E., van Kooten Peter J., ten Brink Corlinda B., Hauet-Broere Femke, Oosterwegel Mariëtte A., Glant Tibor T., Van Eden W., Broeren Chris P., Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation, Journal of Autoimmunity, 25, 3, 2005. Crossref
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Adarichev V.A., Nesterovitch A.B., Jacobs J.J., Glant T.T., Szanto S., Firneisz G., Zhang J., Mikecz K., Finnegan A., Oswald J.P., Disease-Associated Qualitative and Quantitative Trait Loci in Proteoglycan-Induced Arthritis and Collagen-Induced Arthritis, The American Journal of the Medical Sciences, 327, 4, 2004. Crossref
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Glant Tibor T., Radacs Marianna, Nagyeri Gyorgy, Olasz Katalin, Laszlo Anna, Boldizsar Ferenc, Hegyi Akos, Finnegan Alison, Mikecz Katalin, Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis, Arthritis & Rheumatism, 63, 5, 2011. Crossref
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Buzás Edit I., Végvári Anikó, Murad Yanal M., Finnegan Alison, Mikecz Katalin, Glant Tibor T., T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis, Cellular Immunology, 235, 2, 2005. Crossref
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Boldizsar Ferenc, Mikecz Katalin, Glant Tibor T, Immunosenescence and its potential modulation: lessons from mouse models, Expert Review of Clinical Immunology, 6, 3, 2010. Crossref
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Di Paola Rosanna, Cuzzocrea Salvatore, Predictivity and sensitivity of animal models of arthritis, Autoimmunity Reviews, 8, 1, 2008. Crossref
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Adipue Iris A, Wilcox Joel T, King Cody, Rice Carolyn AY, Shaum Katherine M, Suard Cory M, Brink Elri, Miller Stephen D, McMahon Eileen J, Characterization of a novel and spontaneous mouse model of inflammatory arthritis, Arthritis Research & Therapy, 13, 4, 2011. Crossref
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Guichelaar Teun, ten Brink Corlinda B., van Kooten Peter J., Berlo Suzanne E., Lafeber Floris P., Broeren Chris. P., van Eden Willem, Broere Femke, Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis, Molecular Immunology, 45, 13, 2008. Crossref
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Ojeda Gloria, Pini Eliana, Eguiluz César, Montes-Casado María, Broere Femke, van Eden Willem, Rojo Jose M., Portolés Pilar, Complement regulatory protein Crry/p65 costimulation expands natural Treg cells with enhanced suppressive properties in proteoglycan-induced arthritis, Arthritis & Rheumatism, 63, 6, 2011. Crossref
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Ghassemi-Nejad S., Kobezda T., Rauch T.A., Matesz C., Glant T.T., Mikecz K., Osteoarthritis-like damage of cartilage in the temporomandibular joints in mice with autoimmune inflammatory arthritis, Osteoarthritis and Cartilage, 19, 4, 2011. Crossref
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VON HERRATH MATTHIAS, TSOKOS GEORGE C., Animal Models of Autoimmune Disease, in The Autoimmune Diseases, 2006. Crossref
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Kezic Jelena M., Davey Michael P., Glant Tibor T., Rosenbaum James T., Rosenzweig Holly L., Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis, Arthritis & Rheumatism, 64, 3, 2012. Crossref
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Rankin James A., Immunogenetics and rheumatoid arthritis: A review for orthopaedic nurses, Journal of Orthopaedic Nursing, 9, 2, 2005. Crossref
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Egelston Colt, Kurkó Júlia, Besenyei Timea, Tryniszewska Beata, Rauch Tibor A., Glant Tibor T., Mikecz Katalin, Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis, Arthritis & Rheumatism, 64, 10, 2012. Crossref
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Besenyei Timea, Kadar Andras, Tryniszewska Beata, Kurko Julia, Rauch Tibor A., Glant Tibor T., Mikecz Katalin, Szekanecz Zoltan, Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models, Clinical and Developmental Immunology, 2012, 2012. Crossref
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Kezic Jelena M, Glant Tibor T, Rosenbaum James T, Rosenzweig Holly L, Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis, Arthritis Research & Therapy, 14, 1, 2012. Crossref
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Wilson Caroline L., Hine Dominic W., Pradipta Ariel, Pearson Jeffrey P., van Eden Willem, Robinson John H., Knight Andrew M., Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4+ T helper type 1 subset differentiation, Immunology, 135, 4, 2012. Crossref
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Keijzer Chantal, Wieten Lotte, van Herwijnen Martijn, van der Zee Ruurd, Van Eden Willem, Broere Femke, Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions, Expert Opinion on Therapeutic Targets, 16, 9, 2012. Crossref
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Kis-Toth K., Radacs M., Olasz K., van Eden W., Mikecz K., Glant T. T., Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice, International Immunology, 24, 8, 2012. Crossref
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Kobezda Tamás, Ghassemi-Nejad Sheida, Glant Tibor T., Mikecz Katalin, In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis, Cellular Immunology, 278, 1-2, 2012. Crossref
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Haynes Katelin R, Pettit Allison R, Duan Ran, Tseng Hsu-Wen, Glant Tibor T, Brown Matthew A, Thomas Gethin P, Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors, Arthritis Research & Therapy, 14, 6, 2012. Crossref
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Mizui Masayuki, Tsokos George C., Animal Models, in The Autoimmune Diseases, 2014. Crossref
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Misják Petra, Bősze Szilvia, Horváti Kata, Pásztói Mária, Pálóczi Krisztina, Holub Marianna C., Szakács Ferenc, Aradi Borbála, György Bence, Szabó Tamás G., Nagy György, Glant Tibor T., Mikecz Katalin, Falus András, Buzás Edit I., The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis, Immunology Letters, 152, 1, 2013. Crossref
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Kurkó Júlia, Besenyei Timea, Laki Judit, Glant Tibor T., Mikecz Katalin, Szekanecz Zoltán, Genetics of Rheumatoid Arthritis — A Comprehensive Review, Clinical Reviews in Allergy & Immunology, 45, 2, 2013. Crossref
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Ishikawa Larissa Lumi Watanabe, Colavite Priscila Maria, da Rosa Larissa Camargo, Balbino Bianca, França Thais Graziela Donegá, Zorzella-Pezavento Sofia Fernanda Gonçalves, Chiuso-Minicucci Fernanda, Sartori Alexandrina, Commercial Bovine Proteoglycan Is Highly Arthritogenic and Can Be Used as an Alternative Antigen Source for PGIA Model, BioMed Research International, 2014, 2014. Crossref
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Hanyecz A., Olasz K., Tarjanyi O., Nemeth P., Mikecz K., Glant T. T., Boldizsar F., Proteoglycan Aggrecan Conducting T Cell Activation and Apoptosis in a Murine Model of Rheumatoid Arthritis, BioMed Research International, 2014, 2014. Crossref
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Yoshimura Sayuri, Asano Krisana, Nakane Akio, Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan, BioMed Research International, 2014, 2014. Crossref
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Delemarre Eveline M., Roord Sarah T. A., van den Broek Theo, Zonneveld-Huijssoon Evelien, de Jager Wilco, Rozemuller Henk, Martens Anton C., Broere Femke, Wulffraat Nico M., Glant Tibor T., Prakken Berent J., van Wijk Femke, Brief Report: Autologous Stem Cell Transplantation Restores Immune Tolerance in Experimental Arthritis by Renewal and Modulation of the Teff Cell Compartment, Arthritis & Rheumatology, 66, 2, 2014. Crossref
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Petrey Aaron C., de la Motte Carol A., Hyaluronan, a Crucial Regulator of Inflammation, Frontiers in Immunology, 5, 2014. Crossref
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Kobezda Tamás, Ghassemi-Nejad Sheida, Mikecz Katalin, Glant Tibor T., Szekanecz Zoltán, Of mice and men: how animal models advance our understanding of T-cell function in RA, Nature Reviews Rheumatology, 10, 3, 2014. Crossref
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Falconer Jane, Lowes Katie, Furmanski Anna L., Dyson Julian, Ng Wan Fai, Robinson John H., Intramolecular polyspecificity in CD4 T-cell recognition of Ad-restricted epitopes of proteoglycan aggrecan, Immunology, 142, 1, 2014. Crossref
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Swart J F, de Roock S, Hofhuis F M, Rozemuller H, van den Broek T, Moerer P, Broere F, van Wijk F, Kuis W, Prakken B J, Martens A C M, Wulffraat N M, Mesenchymal stem cell therapy in proteoglycan induced arthritis, Annals of the Rheumatic Diseases, 74, 4, 2015. Crossref
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Rosenthal Kenneth S, Mikecz Katalin, Steiner Harold L, Glant Tibor T, Finnegan Alison, Carambula Roy E, Zimmerman Daniel H, Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis, Expert Review of Vaccines, 14, 6, 2015. Crossref
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Lino Andreia C., Dörner Thomas, Bar-Or Amit, Fillatreau Simon, Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases, Immunological Reviews, 269, 1, 2016. Crossref
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Kugyelka Reka, Kohl Zoltan, Olasz Katalin, Mikecz Katalin, Rauch Tibor A., Glant Tibor T., Boldizsar Ferenc, Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis, Mediators of Inflammation, 2016, 2016. Crossref
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Ghassemi Nejad Sheida, Kobezda Tamás, Tar Ildikó, Szekanecz Zoltán, Development of temporomandibular joint arthritis: The use of animal models, Joint Bone Spine, 84, 2, 2017. Crossref
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Delemarre Eveline M., van den Broek Theo, Mijnheer Gerdien, Meerding Jenny, Wehrens Ellen J., Olek Sven, Boes Marianne, van Herwijnen Martijn J. C., Broere Femke, van Royen Annet, Wulffraat Nico M., Prakken Berent J., Spierings Eric, van Wijk Femke, Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells, Blood, 127, 1, 2016. Crossref
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Markovics Adrienn, Ocskó Tímea, Katz Robert S., Buzás Edit I., Glant Tibor T., Mikecz Katalin, Heymann Dominique, Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis, PLOS ONE, 11, 7, 2016. Crossref
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Sardar Samra, Andersson Åsa, Old and new therapeutics for Rheumatoid Arthritis:in vivomodels and drug development, Immunopharmacology and Immunotoxicology, 38, 1, 2016. Crossref
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Atkinson Sara Marie, Nansen Anneline, Pharmacological Value of Murine Delayed-type Hypersensitivity Arthritis: A Robust Mouse Model of Rheumatoid Arthritis in C57BL/6 Mice, Basic & Clinical Pharmacology & Toxicology, 120, 2, 2017. Crossref
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Falconer Jane, Mahida Rahul, Venkatesh Divya, Pearson Jeffrey, Robinson John H., Unconventional T-cell recognition of an arthritogenic epitope of proteoglycan aggrecan released from degrading cartilage, Immunology, 147, 4, 2016. Crossref
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Ishikawa Larissa Lumi Watanabe, Colavite Priscila Maria, Fraga-Silva Thais Fernanda de Campos, Mimura Luiza Ayumi Nishiyama, França Thais Graziela Donegá, Zorzella-Pezavento Sofia Fernanda Gonçalves, Chiuso-Minicucci Fernanda, Marcolino Larissa Doddi, Marques Camila, Ikoma Maura Rosane Valerio, Sartori Alexandrina, Systemic Administration of Proteoglycan Protects BALB/c Retired Breeder Mice from Experimental Arthritis, Journal of Immunology Research, 2016, 2016. Crossref
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Adarichev Vyacheslav A., Vermes Csaba, Hanyecz Anita, Ludanyi Katalin, Tunyogi-Csapo Miklos, Finnegan Alison, Mikecz Katalin, Glant Tibor T., Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis, Autoimmunity, 39, 8, 2006. Crossref
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Kurkó Júlia, Vida András, Ocskó Tímea, Tryniszewska Beata, Rauch Tibor A., Glant Tibor T., Szekanecz Zoltán, Mikecz Katalin, Frey Oliver, Suppression of Proteoglycan-Induced Autoimmune Arthritis by Myeloid-Derived Suppressor Cells Generated In Vitro from Murine Bone Marrow, PLoS ONE, 9, 11, 2014. Crossref
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Mikecz Katalin, Glant Tibor T., Markovics Adrienn, Rosenthal Kenneth S., Kurko Julia, Carambula Roy E., Cress Steve, Steiner Harold L., Zimmerman Daniel H., An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis, Vaccine, 35, 32, 2017. Crossref
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Wieten Lotte, Berlo Suzanne E., ten Brink Corlinda B., van Kooten Peter J., Singh Mahavir, van der Zee Ruurd, Glant Tibor T., Broere Femke, van Eden Willem, Pockley Graham, IL-10 Is Critically Involved in Mycobacterial HSP70 Induced Suppression of Proteoglycan-Induced Arthritis, PLoS ONE, 4, 1, 2009. Crossref
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Choudhary Narayan, Bhatt Lokesh K., Prabhavalkar Kedar S., Experimental animal models for rheumatoid arthritis, Immunopharmacology and Immunotoxicology, 40, 3, 2018. Crossref
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Koenders Marije I., van den Berg Wim B., Critical role of IL-17 in experimental arthritis, in Th 17 Cells: Role in Inflammation and Autoimmune Disease, 2009. Crossref
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Hamel Keith M., Cao Yanxia, Ashaye Susan, Wang Yumei, Dunn Robert, Kehry Marilyn R., Glant Tibor T., Finnegan Alison, B Cell Depletion Enhances T Regulatory Cell Activity Essential in the Suppression of Arthritis, The Journal of Immunology, 187, 9, 2011. Crossref
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Sarraj Bara, Ludányi Katalin, Glant Tibor T., Finnegan Alison, Mikecz Katalin, Expression of CD44 and L-Selectin in the Innate Immune System Is Required for Severe Joint Inflammation in the Proteoglycan-Induced Murine Model of Rheumatoid Arthritis, The Journal of Immunology, 177, 3, 2006. Crossref
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Ibañez Olga Martinez, Jensen José Ricardo, Franco Marcelo De, Transcriptome Profiling in Experimental Inflammatory Arthritis, in Transcriptomics in Health and Disease, 2014. Crossref
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Rodeghero Rachel, Cao Yanxia, Olalekan Susan A., Iwakua Yoichiro, Glant Tibor T., Finnegan Alison, Location of CD4+ T Cell Priming Regulates the Differentiation of Th1 and Th17 Cells and Their Contribution to Arthritis, The Journal of Immunology, 190, 11, 2013. Crossref
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Doodes Paul D., Cao Yanxia, Hamel Keith M., Wang Yumei, Farkas Balint, Iwakura Yoichiro, Finnegan Alison, Development of Proteoglycan-Induced Arthritis Is Independent of IL-17, The Journal of Immunology, 181, 1, 2008. Crossref
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Szántó Sándor, Gál István, Gonda Andrea, Glant Tibor T., Mikecz Katalin, Expression of L-Selectin, but Not CD44, Is Required for Early Neutrophil Extravasation in Antigen-Induced Arthritis, The Journal of Immunology, 172, 11, 2004. Crossref
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Hamel Keith, Doodes Paul, Cao Yanxia, Wang Yumei, Martinson Jeffrey, Dunn Robert, Kehry Marilyn R., Farkas Balint, Finnegan Alison, Suppression of Proteoglycan-Induced Arthritis by Anti-CD20 B Cell Depletion Therapy Is Mediated by Reduction in Autoantibodies and CD4+T Cell Reactivity, The Journal of Immunology, 180, 7, 2008. Crossref
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Broere Femke, Berlo Suzanne E., Guichelaar Teun, Wieten Lotte, Van Der Zee Ruurd, Van Eden Willem, HSP Reactive T Cells are Anti-Inflammatory and Disease Suppressive in Arthritic Diseases, in Heat Shock Proteins and Whole Body Physiology, 5, 2010. Crossref
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Jansen Manon A. A., Spiering Rachel, Ludwig Irene S., van Eden Willem, Hilkens Catharien M. U., Broere Femke, Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4+ T Cells in a Murine Arthritis Model, Frontiers in Immunology, 10, 2019. Crossref
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Sandor Katalin, Nandakumar Kutty Selva, Holmdahl Rikard, Svensson Camilla I., Collagen Antibody-Induced Arthritis: A Disease-Relevant Model for Studies of Persistent Joint Pain, in TRP Channels in Drug Discovery, 2012. Crossref
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Glant Tibor T., Szántó Sándor, Vegvari Aniko, Szabo Zoltan, Kis-Toth Katalin, Mikecz Katalin, Adarichev Vyacheslav A., Two Loci on Chromosome 15 Control Experimentally Induced Arthritis through the Differential Regulation of IL-6 and Lymphocyte Proliferation, The Journal of Immunology, 181, 2, 2008. Crossref
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Guichelaar Teun, ten Brink Corlinda B., van Kooten Peter J., Berlo Suzanne E., Broeren Chris P., van Eden Willem, Broere Femke, Autoantigen-Specific IL-10-Transduced T Cells Suppress Chronic Arthritis by Promoting the Endogenous Regulatory IL-10 Response, The Journal of Immunology, 180, 3, 2008. Crossref
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Mia Md. Younus, Durai Malarvizhi, Kim Hong Ro, Moudgil Kamal D., Heat Shock Protein 65-Reactive T Cells Are Involved in the Pathogenesis of Non-Antigenic Dimethyl Dioctadecyl Ammonium Bromide-Induced Arthritis, The Journal of Immunology, 175, 1, 2005. Crossref
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O’Neill Shannon K., Shlomchik Mark J., Glant Tibor T., Cao Yanxia, Doodes Paul D., Finnegan Alison, Antigen-Specific B Cells Are Required as APCs and Autoantibody-Producing Cells for Induction of Severe Autoimmune Arthritis, The Journal of Immunology, 174, 6, 2005. Crossref
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Koenders Marije I., van den Berg Wim B., Critical Role of IL-17 in Experimental Arthritis, in IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity, 2013. Crossref
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Cao Yanxia, Doodes Paul D., Glant Tibor T., Finnegan Alison, IL-27 Induces a Th1 Immune Response and Susceptibility to Experimental Arthritis, The Journal of Immunology, 180, 2, 2008. Crossref
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Markovics Adrienn, Toth Daniel M., Glant Tibor T., Mikecz Katalin, Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase, Arthritis Research & Therapy, 22, 1, 2020. Crossref
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Hu Zi-Bing, Wei Bo, Wu Shao-Ke, Sun Jie-Cong, Xiang Min, Zhang Zhong-Min, Changes in bone mineral density and bone metabolic indexes in ankylosing spondylitis mouse model complicated with osteoporosis, Experimental and Therapeutic Medicine, 2018. Crossref
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Mizui Masayuki, Tsokos George C., Animal Models: Systemic Autoimmune Diseases, in The Autoimmune Diseases, 2020. Crossref
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Romero-López José Pablo, Elewaut Dirk, Pacheco-Tena César, Burgos-Vargas Rubén, Inflammatory Foot Involvement in Spondyloarthritis: From Tarsitis to Ankylosing Tarsitis, Frontiers in Medicine, 8, 2021. Crossref
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Tarjanyi Oktavia, Boldizsar Ferenc, Nemeth Peter, Mikecz Katalin, Glant Tibor T, Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis, Immunity & Ageing, 6, 1, 2009. Crossref
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Olasz K, Boldizsar F, Kis-Toth K, Tarjanyi O, Hegyi A, van Eden W, Rauch T A, Mikecz K, Glant T T, T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice, Clinical and Experimental Immunology, 167, 2, 2012. Crossref
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Adarichev V A, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Glant T T, Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation, Genes & Immunity, 9, 7, 2008. Crossref
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Glant T T, Adarichev V A, Boldizsar F, Besenyei T, Laszlo A, Mikecz K, Rauch T A, Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis, Genes & Immunity, 13, 4, 2012. Crossref
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Murad Y M, Szabó Z, Ludányi K, Glant T T, Molecular manipulation with the arthritogenic epitopes of the G1 domain of human cartilage proteoglycan aggrecan, Clinical and Experimental Immunology, 142, 2, 2005. Crossref
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Nagyeri Gyorgy, Radacs Marianna, Ghassemi-Nejad Sheida, Tryniszewska Beata, Olasz Katalin, Hutas Gabor, Gyorfy Zsuzsa, Hascall Vincent C., Glant Tibor T., Mikecz Katalin, TSG-6 Protein, a Negative Regulator of Inflammatory Arthritis, Forms a Ternary Complex with Murine Mast Cell Tryptases and Heparin, Journal of Biological Chemistry, 286, 26, 2011. Crossref
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Ibañez Olga Martinez, Jensen José Ricardo, De Franco Marcelo, Transcriptome Profiling in Experimental Inflammatory Arthritis, in Transcriptomics in Health and Disease, 2022. Crossref
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Abdel Jaleel Gehad A., Azab Samar S., el-Bakly Wesam M., Hassan Azza, 'Methyl palmitate attenuates adjuvant induced arthritis in rats by decrease of CD68 synovial macrophages, Biomedicine & Pharmacotherapy, 137, 2021. Crossref
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von Mentzer Ula, Corciulo Carmen, Stubelius Alexandra, Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular Matrix, Macromolecular Bioscience, 22, 7, 2022. Crossref