Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Structure and Function of the CD7 Molecule
RÉSUMÉ
CD7 is a single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-l+ adult T-cell leukemia cells. Because of lack of identification of a natural ligand and lack of a monoclonal antibody against murine CD7, the in vivo functions of CD7 have until recently remained obscure. Recent studies in CD7-deficient mice have provided new insights into CD7 function, and demonstrated key roles for CD7 in regulating peripheral T and NK cell cytokine production and sensitivity to LPS-induced shock syndromes. This article reviews recent work on the expression, structure, and function of CD7, and discusses roles the CD7 molecule might play in T and NK cell development and function.
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Kosugi Nobuharu, Ebihara Yasuhiro, Nakahata Tatsutoshi, Saisho Hiromitsu, Asano Shigetaka, Tojo Arinobu, CD34+CD7+ Leukemic Progenitor Cells May Be Involved in Maintenance and Clonal Evolution of Chronic Myeloid Leukemia, Clinical Cancer Research, 11, 2, 2005. Crossref
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Hernandez Joseph D., Nguyen Julie T., He Jiale, Wang Wei, Ardman Blair, Green Jonathan M., Fukuda Minoru, Baum Linda G., Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death, The Journal of Immunology, 177, 8, 2006. Crossref
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Pace Karen E., Hahn Hejin P., Pang Mabel, Nguyen Julie T., Baum Linda G., Cutting Edge: CD7 Delivers a Pro-Apoptotic Signal During Galectin-1-Induced T Cell Death, The Journal of Immunology, 165, 5, 2000. Crossref
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Assi Rita, Salman Huda, Harnessing the Potential of Chimeric Antigen Receptor T-Cell Therapy for the Treatment of T-Cell Malignancies: A Dare or Double Dare?, Cells, 11, 24, 2022. Crossref