Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Victory and Defeat in the Induction of a Therapeutic Response through Vaccine Therapy for Human and Canine Brain Tumors: A Review of the State of the Art
RÉSUMÉ
Anti-tumor immunotherapy using tumor lysate−based vaccines has made great advances over recent decades. Cancer vaccines aim to elicit adaptive immune responses through various pathways by providing tumor and tumor-associated antigens with an immune stimulant or adjuvant. These anti-tumor vaccines are therefore developed as personalized treatments. Utilizing tumors as a source of vaccine antigens in immunotherapy has demonstrated promising results with minimal toxicity. However, to date, researchers have failed to overcome the overpowering immune suppressive effects within the tumor microenvironment. Immune suppression occurs naturally via multiple mechanisms. These mechanisms serve an important homeostatic role restoring a normal tissue microenvironment following an inflammatory response. Due to these suppressive mechanisms and the inherent heterogeneity of tumors, it is imperative to then elicit and maintain a specific tumoricidal response if vaccine therapy or some other combination of reagents is chosen. In this review, we focus on the historical use of tumors as a source of antigens to elicit a tumoricidal response and the limitations encountered that prevent greater success in immunotherapy. We describe the advantages and disadvantages of various vaccines and their ineffectiveness due to tumor-induced immune suppression.
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LeBlanc Amy K., Mazcko Christina, Brown Diane E., Koehler Jennifer W., Miller Andrew D., Miller C. Ryan, Bentley R. Timothy, Packer Rebecca A., Breen Matthew, Boudreau C. Elizabeth, Levine Jonathan M., Simpson R. Mark, Halsey Charles, Kisseberth William, Rossmeisl John H., Dickinson Peter J., Fan Timothy M., Corps Kara, Aldape Kenneth, Puduvalli Vinay, Pluhar G. Elizabeth, Gilbert Mark R., Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients, Neuro-Oncology, 18, 9, 2016. Crossref
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Clemen Ramona, Bekeschus Sander, ROS Cocktails as an Adjuvant for Personalized Antitumor Vaccination?, Vaccines, 9, 5, 2021. Crossref
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Nemec Paige S., Holmes Jennifer C., Hess Paul R., Dog leukocyte antigen‐88*034:01 presents nonamer peptides from canine distemper virus hemagglutinin, large polymerase, and matrix proteins, HLA, 97, 5, 2021. Crossref
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Chen Li-Jeng, Hsu Tsai-Ching, Yeh Pei-Jung, Yow Jia Le, Chang Chia-Ling, Lin Cheng-Hui, Tzang Bor-Show, Differential Effects of Wedelia chinensis on Human Glioblastoma Multiforme Cells, Integrative Cancer Therapies, 20, 2021. Crossref
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Xiong Zhengming, Ampudia-Mesias Elisabet, Shaver Rob, Horbinski Craig M, Moertel Christopher L, Olin Michael R, Tumor-derived vaccines containing CD200 inhibit immune activation: implications for immunotherapy, Immunotherapy, 8, 9, 2016. Crossref
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Packer Rebecca A., Nervous System, in Veterinary Surgical Oncology, 2022. Crossref
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Sokolov Aleksandr V., Dostdar Samira A., Attwood Misty M., Krasilnikova Aleksandra A., Ilina Anastasia A., Nabieva Amina Sh., Lisitsyna Anna A., Chubarev Vladimir N., Tarasov Vadim V., Schiöth Helgi B., Gottesman Michael, Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies, Pharmacological Reviews, 73, 4, 2021. Crossref
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Withers Sita S., Sparger Ellen E., Boudreaux Bonnie, Mason Nicola J., Utilizing Microbes to Treat Naturally Occurring Cancer in Veterinary Species, Current Clinical Microbiology Reports, 6, 4, 2019. Crossref