Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
The Immune System in the Pathogenesis of Ovarian Cancer
RÉSUMÉ
Clinical outcomes in ovarian cancer are heterogeneous even when considering common features such as stage, response to therapy, and grade. This disparity in outcomes warrants further exploration into tumor and host characteristics. One compelling host characteristic is the immune response to ovarian cancer. While several studies have confirmed a prominent role for the immune system in modifying the clinical course of the disease, recent genetic and protein analyses also suggest a role in disease incidence. Recent studies also show that anti-tumor immunity is often negated by immune suppressive cells present in the tumor microenvironment. These suppressive immune cells also directly enhance the pathogenesis through the release of various cytokines and chemokines, which together form an integrated pathologic network. Thus, future research into immunotherapy targeting ovarian cancer will likely become increasingly focused on combination approaches that simultaneously augment immunity while preventing local immune suppression or by disrupting critical cytokine networks.
-
Legitimo Annalisa, Consolini Rita, Failli Alessandra, Orsini Giulia, Spisni Roberto, Dendritic cell defects in the colorectal cancer, Human Vaccines & Immunotherapeutics, 10, 11, 2014. Crossref
-
Poggi Alessandro, Musso Alessandra, Dapino Irene, Zocchi Maria Raffaella, Mechanisms of tumor escape from immune system: Role of mesenchymal stromal cells, Immunology Letters, 159, 1-2, 2014. Crossref
-
Zhao Sanhu, Yang Yanyong, Liu Wen, Xuan Zhiqiang, Wu Shouming, Yu Shunfei, Mei Ke, Huang Yijuan, Zhang Pei, Cai Jianming, Ni Jin, Zhao Yaoxian, Protective effect of hydrogen‐rich saline against radiation‐induced immune dysfunction, Journal of Cellular and Molecular Medicine, 18, 5, 2014. Crossref
-
Gujar Shashi A., Lee Patrick W. K., Oncolytic Virus-Mediated Reversal of Impaired Tumor Antigen Presentation, Frontiers in Oncology, 4, 2014. Crossref
-
Hung Rayjean J., Ulrich Cornelia M., Goode Ellen L., Brhane Yonathan, Muir Kenneth, Chan Andrew T., Marchand Loic Le, Schildkraut Joellen, Witte John S., Eeles Rosalind, Boffetta Paolo, Spitz Margaret R., Poirier Julia G., Rider David N., Fridley Brooke L., Chen Zhihua, Haiman Christopher, Schumacher Fredrick, Easton Douglas F., Landi Maria Teresa, Brennan Paul, Houlston Richard, Christiani David C., Field John K., Bickeböller Heike, Risch Angela, Kote-Jarai Zsofia, Wiklund Fredrik, Grönberg Henrik, Chanock Stephen, Berndt Sonja I., Kraft Peter, Lindström Sara, Al Olama Ali Amin, Song Honglin, Phelan Catherine, Wentzensen Nicholas, Peters Ulrike, Slattery Martha L., Sellers Thomas A., Casey Graham, Gruber Stephen B., Hunter David J., Amos Christopher I., Henderson Brian, Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer, Journal of the National Cancer Institute, 107, 11, 2015. Crossref
-
Dijkgraaf E.M., Santegoets S.J.A.M., Reyners A.K.L., Goedemans R., Wouters M.C.A., Kenter G.G., van Erkel A.R., van Poelgeest M.I.E., Nijman H.W., van der Hoeven J.J.M., Welters M.J.P., van der Burg S.H., Kroep J.R., A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer, Annals of Oncology, 26, 10, 2015. Crossref
-
Knutson Keith L., Maurer Matthew J., Preston Claudia C., Moysich Kirsten B., Goergen Krista, Hawthorne Kieran M., Cunningham Julie M., Odunsi Kunle, Hartmann Lynn C., Kalli Kimberly R., Oberg Ann L., Goode Ellen L., Regulatory T cells, inherited variation, and clinical outcome in epithelial ovarian cancer, Cancer Immunology, Immunotherapy, 64, 12, 2015. Crossref
-
Wang Dong-hui, Wu Xiao-hua, Qian Su-min, Yao Hai-Rong, Study on the mesothelin-specific cytotoxicity against epithelial ovarian cancer with full-length mesothelin cDNA-transduced dendritic cells, Medical Oncology, 32, 4, 2015. Crossref
-
Sage Eva K., Schmid Thomas E., Sedelmayr Michael, Gehrmann Mathias, Geinitz Hans, Duma Marciana N., Combs Stephanie E., Multhoff Gabriele, Comparative analysis of the effects of radiotherapy versus radiotherapy after adjuvant chemotherapy on the composition of lymphocyte subpopulations in breast cancer patients, Radiotherapy and Oncology, 118, 1, 2016. Crossref
-
Singh Manindra, Loftus Tiffany, Webb Erin, Benencia Fabian, Minireview: Regulatory T Cells and Ovarian Cancer, Immunological Investigations, 45, 8, 2016. Crossref
-
Cannioto Rikki A., Sucheston-Campbell Lara E., Hampras Shalaka, Goode Ellen L., Knutson Keith, Ness Roberta, Modugno Francesmary, Wallace Paul K., Szender J. Brian, Mayor Paul, Hong Chi-Chen, Joseph Janine M., Friel Grace, Davis Warren, Nesline Mary, Eng Kevin H., Edwards Robert P., Kruszka Bridget, Schmitt Kristina, Odunsi Kunle, Moysich Kirsten B., The Association of Peripheral Blood Regulatory T-Cell Concentrations With Epithelial Ovarian Cancer: A Brief Report, International Journal of Gynecologic Cancer, 27, 1, 2017. Crossref
-
Okła Karolina, Wertel Iwona, Polak Grzegorz, Surówka Justyna, Wawruszak Anna, Kotarski Jan, Tumor-Associated Macrophages and Myeloid-Derived Suppressor Cells as Immunosuppressive Mechanism in Ovarian Cancer Patients: Progress and Challenges, International Reviews of Immunology, 35, 5, 2016. Crossref
-
da Silva Rodrigo, Yoshida Adriana, Cardozo Daniela, Jales Rodrigo, Paust Silke, Derchain Sophie, Guimarães Fernando, Natural Killer Cells Response to IL-2 Stimulation Is Distinct between Ascites with the Presence or Absence of Malignant Cells in Ovarian Cancer Patients, International Journal of Molecular Sciences, 18, 5, 2017. Crossref
-
Wu Meng, Chen Xian, Lou Jianfang, Zhang Shuping, Zhang Xiaojie, Huang Lei, Sun Ruihong, Huang Peijun, Pan Shiyang, Wang Fang, Changes in regulatory T cells in patients with ovarian cancer undergoing surgery: Preliminary results, International Immunopharmacology, 47, 2017. Crossref
-
Ingerslev Kasper, Hogdall Estrid, Schnack Tine Henrichsen, Skovrider-Ruminski Wojciech, Hogdall Claus, Blaakaer Jan, The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis, Infectious Agents and Cancer, 12, 1, 2017. Crossref
-
Wilson Amy, Wilson Kirsty, Bilandzic Maree, Moffitt Laura, Makanji Ming, Gorrell Mark, Oehler Martin, Rainczuk Adam, Stephens Andrew, Plebanski Magdalena, Non-Invasive Fluorescent Monitoring of Ovarian Cancer in an Immunocompetent Mouse Model, Cancers, 11, 1, 2018. Crossref
-
Jiang Li, Fang Xuhong, Wang Hong, Li Diyou, Wang Xipeng, Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells, Frontiers in Immunology, 9, 2018. Crossref
-
McCloskey Curtis, Rodriguez Galaxia, Galpin Kristianne, Vanderhyden Barbara, Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics, Cancers, 10, 8, 2018. Crossref
-
Carter Lauren E., Cook David P., Vanderhyden Barbara C., Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer, in The Ovary, 2019. Crossref
-
Urzua Ulises, Chacon Carlos, Lizama Luis, Sarmiento Sebastián, Villalobos Pía, Kroxato Belén, Marcelain Katherine, Gonzalez María-Julieta, Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice, Aging and disease, 8, 5, 2017. Crossref
-
Pinto Mauricio P., Balmaceda Carlos, Bravo Maria L., Kato Sumie, Villarroel Alejandra, Owen Gareth I., Roa Juan Carlos, Cuello Mauricio A., Ibañez Carolina, Patient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer, Gynecologic Oncology, 151, 1, 2018. Crossref
-
Tanyi Janos, Facciabene Andrea, The Microbiota and Ovarian Cancer, in Microbiome and Cancer, 2019. Crossref
-
Qin Yujing, Li Wenxue, Long Yingli, Zhan Zhijia, Relationship between p-cofilin and cisplatin resistance in patients with ovarian cancer and the role of p-cofilin in prognosis, Cancer Biomarkers, 24, 4, 2019. Crossref
-
Cho Youngwoo, Milane Lara, Amiji Mansoor M., Genetic and epigenetic strategies for advancing ovarian cancer immunotherapy, Expert Opinion on Biological Therapy, 19, 6, 2019. Crossref
-
Nakamura Mano, Bax Heather J., Scotto Daniele, Souri Elmira Amiri, Sollie Sam, Harris Robert J., Hammar Niklas, Walldius Goran, Winship Anna, Ghosh Sharmistha, Montes Ana, Spicer James F., Van Hemelrijck Mieke, Josephs Debra H., Lacy Katie E., Tsoka Sophia, Karagiannis Sophia N., Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma, OncoImmunology, 8, 6, 2019. Crossref
-
Gagno Sara, Poletto Elena, Bartoletti Michele, Quartuccio Luca, Romualdi Chiara, Garziera Marica, Scalone Simona, Sorio Roberto, Dreussi Eva, Zanusso Chiara, De Mattia Elena, Roncato Rossana, Cecchin Erika, Giorda Giorgio, De Vita Salvatore, Dal Bo Michele, Puglisi Fabio, Toffoli Giuseppe, A TGF-β associated genetic score to define prognosis and platinum sensitivity in advanced epithelial ovarian cancer, Gynecologic Oncology, 156, 1, 2020. Crossref
-
Markin L., Besedin O., Isayeva K., Doroshenko-Kravchyk M., Etiopathogenesis and Histogenesis of Ovarian Tumors, Lviv clinical bulletin, 1, 29, 2020. Crossref
-
Wu Meng, Chen Xian, Lou Jianfang, Zhang Shuping, Zhang Xiaojie, Huang Lei, Sun Ruihong, Huang Peijun, Wang Fang, Pan Shiyang, TGF-β1 contributes to CD8+ Treg induction through p38 MAPK signaling in ovarian cancer microenvironment, Oncotarget, 7, 28, 2016. Crossref
-
Zhang Lixia , Liu Weiwei , Wang Xinbo , Wang Xiaoli , Sun Hong , Prognostic value of serum IL-8 and IL-10 in patients with ovarian cancer undergoing chemotherapy, Oncology Letters, 2018. Crossref
-
Li Dong-feng, Tulahong Aisikeer, Uddin Md. Nazim, Zhao Huan, Zhang Hua, Meta-analysis identifying epithelial-derived transcriptomes predicts poor clinical outcome and immune infiltrations in ovarian cancer, Quantitative Finance and Economics, 18, 5, 2021. Crossref
-
Chang Cherry Yin-Yi, Lin Kent Yu-Hsien, Huang Chien-Chu, Lin Wu-Chou, Association of pelvic inflammatory disease (PID) with ovarian cancer: a nationwide population-based retrospective cohort study from Taiwan, BMC Women's Health, 21, 1, 2021. Crossref
-
Xu Hao, Ding Yuan, Yang Xiangying, Yi Ming, Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells, BioMed Research International, 2021, 2021. Crossref
-
Lamichhane Purushottam, Karyampudi Lavakumar, Shreeder Barath, Krempski James, Bahr Deborah, Daum Joshua, Kalli Kimberly R., Goode Ellen L., Block Matthew S., Cannon Martin J., Knutson Keith L., IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer, Cancer Research, 77, 23, 2017. Crossref
-
Ma Rui, Chu Xiaolin, Jiang Yiting, Xu Qing, Pigment epithelium-derived factor, an anti-VEGF factor, delays ovarian cancer progression by alleviating polarization of tumor-associated macrophages, Cancer Gene Therapy, 2022. Crossref
-
Liu Ye, Ng Michael K., A new clustering algorithm for genes with multiple cancer diseases by self-consistent field iteration method, Network Modeling Analysis in Health Informatics and Bioinformatics, 11, 1, 2022. Crossref
-
Lee Amy H., Mejia Peña Carolina, Dawson Michelle R., Comparing the Secretomes of Chemorefractory and Chemoresistant Ovarian Cancer Cell Populations, Cancers, 14, 6, 2022. Crossref
-
Khetan Riya, Dharmayanti Cintya, Gillam Todd A., Kübler Eric, Klingler-Hoffmann Manuela, Ricciardelli Carmela, Oehler Martin K., Blencowe Anton, Garg Sanjay, Albrecht Hugo, Using GPCRs as Molecular Beacons to Target Ovarian Cancer with Nanomedicines, Cancers, 14, 10, 2022. Crossref
-
Stejskalová Anna, Vankelecom Hugo, Sourouni Marina, Ho Magdalene Y, Götte Martin, Almquist Benjamin D, In vitro modelling of the physiological and diseased female reproductive system, Acta Biomaterialia, 132, 2021. Crossref
-
Mahoney Diane E., Chalise Prabhakar, Rahman Faith, Pierce Janet D., Influences of Gastrointestinal Microbiota Dysbiosis on Serum Proinflammatory Markers in Epithelial Ovarian Cancer Development and Progression, Cancers, 14, 12, 2022. Crossref
-
Mogos Raluca, Popovici Razvan, Tanase Adina, Calistru Tudor, Popovici Paula, Grigore Mihaela, Carauleanu Alexandru, New approaches in ovarian cancer based on genetics and carcinogenesis hypotheses (Review), Experimental and Therapeutic Medicine, 23, 6, 2022. Crossref
-
Saburi Ahmad, Kahrizi Mohammad Saeed, Naghsh Navid, Etemadi Hasti, İlhan Ahmet, Adili Ali, Ghoreishizadeh Shadi, Tamjidifar Rozita, Akbari Morteza, Ercan Gülinnaz, A comprehensive survey into the role of microRNAs in ovarian cancer chemoresistance; an updated overview, Journal of Ovarian Research, 15, 1, 2022. Crossref
-
Börner Clara, Scheerer Claudia, Buschow Rene, Chiantera Vito, Sehouli Jalid, Mechsner Sylvia, Pain Mechanisms in Peritoneal Diseases Might Be Partially Regulated by Estrogen, Reproductive Sciences, 25, 3, 2018. Crossref
-
Eldefrawy Fatma, Xu Hannah Shibo, Pusch Elizabeth, Karkoura Ashraf, Alsafy Mohamed, Elgendy Samir, Williams Susan M., Navara Kristen, Guo Tai L., Modulation of folliculogenesis in adult laying chickens by bisphenol A and bisphenol S: Perspectives on ovarian morphology and gene expression, Reproductive Toxicology, 103, 2021. Crossref
-
Shekhar Shashank, Yadav Amit K., Khosla Ajit, Solanki Pratima R., Review—Interleukins Profiling for Biosensing Applications: Possibilities and the Future of Disease Detection, ECS Sensors Plus, 1, 4, 2022. Crossref
-
Almolakab Zainab M., El-Nesr Khalid A., Mohamad Ehab H., Elkaffas Rasha, Nabil Ahmed, Gene polymorphisms of interleukin 10 (− 819 C/T and − 1082 G/A) in women with ovarian cancer, Beni-Suef University Journal of Basic and Applied Sciences, 11, 1, 2022. Crossref