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Critical Reviews™ in Immunology

Publication de 6  numéros par an

ISSN Imprimer: 1040-8401

ISSN En ligne: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Intraepithelial Lymphocytes: Origins, Distribution, and Function

Volume 18, Numéro 3, 1998, pp. 237-254
DOI: 10.1615/CritRevImmunol.v18.i3.40
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RÉSUMÉ

Intraepithelial lymphocytes (IEL) are associated with the intestinal tract, respiratory tract, genitourinary tract epithelium, and the skin and are the first immune system cells to encounter pathogens that have invaded an epithelial surface. IEL are predominantly T cells (CD3+) with CD8+ cells predominating at most, but not all, sites. Both TCRαβ+ and TCRγδ+ cells are found within IEL populations and an increasing body of evidence suggests that some IEL may arise extrathymically. The presence within intestinal IEL of cells expressing potentially self-reactive TCR suggests that T cell selection within epithelia may differ from thymic T cell selection although recent evidence suggests that these cells may in fact be nonresponsive. IEL exhibit various cytotoxic activities including alloreactive and virus-specific CTL activity, NK activity and spontaneous cytotoxicity, activities consistent with an immune surveillance or first line of defence role. IEL also appear activated in vivo and secrete a variety of cytokines. Subsets of IEL have been shown to provide B cell help, to play a role in the maintenance of oral tolerance and to regulate epithelial cell function. In this review the morphology, distribution and phenotype of IEL, the potential for extrathymic development and possible functions of this unique lymphoid population are discussed.

CITÉ PAR
  1. Intestine, in Jubb, Kennedy & Palmer's Pathology of Domestic Animals, 2007. Crossref

  2. Kaneko Masahiro, Mizunuma Tsunehide, Takimoto Hiroaki, Kumazawa Yoshio, Development of TCR.ALPHA..BETA. CD8.ALPHA..ALPHA. Intestinal Intraepithelial Lymphocytes Is Promoted by Interleukin-15-Producing Epithelial Cells Constitutively Stimulated by Gram-Negative Bacteria via TLR4, Biological and Pharmaceutical Bulletin, 27, 6, 2004. Crossref

  3. Kronenberg Mitchell, Cheroutre Hilde, Development, Function, and Specificity of Intestinal Intraepithelial Lymphocytes, in Mucosal Immunology, 2005. Crossref

  4. MacDonald Thomas T., The mucosal immune system, Parasite Immunology, 25, 5, 2003. Crossref

  5. Forest Virginie, Pierre Fabrice, Bassonga Euph�mie, Meflah Khaled, Menanteau Jean, Large intestine intraepithelial lymphocytes from Apc+/+ and Apc+/Min mice and their modulation by indigestible carbohydrates: the IL-15/IL-15R? complex and CD4+CD25+ T cells are the main targets, Cancer Immunology, Immunotherapy, 54, 1, 2005. Crossref

  6. Laouar Amale, Haridas Viraga, Vargas Dorothy, Zhinan Xia, Chaplin David, van Lier Rene A W, Manjunath N, CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa, Nature Immunology, 6, 7, 2005. Crossref

  7. Lambert Claude, Genin Christian, CD3 bright lymphocyte population reveal ?? T cells, Cytometry, 61B, 1, 2004. Crossref

  8. Furukawa Hiroo, Asai Satoshi, Moriyasu Takayuki, Ono Hisako, Saiga Tatsuyoshi, Three‐Dimensional Reconstruction of the Mucosa from Sequential Sections of Biopsy Specimens for Understanding Disease Progress in Ulcerative Colitis, Digestive Endoscopy, 12, 4, 2000. Crossref

  9. Mak Tak W., Saunders Mary E., Mucosal and Cutaneous Immunity, in The Immune Response, 2006. Crossref

  10. Bukovsky Antonin, Caudle Michael R, Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial, Reproductive Biology and Endocrinology, 10, 1, 2012. Crossref

  11. Ogata Masaki, Ota Yuta, Matsutani Takaji, Nanno Masanobu, Suzuki Ryuji, Itoh Tsunetoshi, Granzyme B-dependent and perforin-independent DNA fragmentation in intestinal epithelial cells induced by anti-CD3 mAb-activated intra-epithelial lymphocytes, Cell and Tissue Research, 352, 2, 2013. Crossref

  12. Colgan Sean P., Curtis Valerie F., Campbell Eric L., The Inflammatory Tissue Microenvironment in IBD, Inflammatory Bowel Diseases, 19, 10, 2013. Crossref

  13. Li Q. R., Wang C. Y., Tang C., He Q., Li N., Li J. S., Reciprocal Interaction Between Intestinal Microbiota and Mucosal Lymphocyte in Cynomolgus Monkeys After Alemtuzumab Treatment, American Journal of Transplantation, 13, 4, 2013. Crossref

  14. Aswald Jorg M., Wang Xing-Hua, Aswald Sandra, Lutynski Andrzej, Minden Mark D., Messner Hans A., Keating Armand, Flow cytometric assessment of autologous γδ T cells in patients with acute myeloid leukemia: Potential effector cells for immunotherapy?, Cytometry Part B: Clinical Cytometry, 70B, 6, 2006. Crossref

  15. Bukovsky Antonin, Immune system involvement in the regulation of ovarian function and augmentation of cancer, Microscopy Research and Technique, 69, 6, 2006. Crossref

  16. Bukovsky Antonin, Virant‐Klun Irma, Svetlikova Marta, Willson Isabelle, Ovarian Germ Cells, in Adult Stem Cells, 419, 2006. Crossref

  17. Tóth Štefan, Jonecová Zuzana, Varga Ján, Staško Pavel, Kovalčinová Barbora, Maretta Milan, Leško Dušan, Veselá Jarmila, Immunohistochemical study of jejunal graft mucosa cell populations during the initial adaptation phase in the host body in rats, Acta Histochemica, 115, 8, 2013. Crossref

  18. Bukovsky Antonin, Caudle Michael R., REVIEW ARTICLE: Immune Physiology of the Mammalian Ovary - A Review, American Journal of Reproductive Immunology, 59, 1, 2007. Crossref

  19. Yada Shinichiro, Nukina Hideyuki, Kishihara Kenji, Takamura Noriaki, Yoshida Hiroki, Inagaki-Ohara Kyoko, Nomoto Kikuo, Lin Tesu, IL-7 Prevents Both Caspase-Dependent and -Independent Pathways That Lead to the Spontaneous Apoptosis of i-IEL, Cellular Immunology, 208, 2, 2001. Crossref

  20. Kosiewicz Michele M., Nast Cynthia C., Krishnan Anasuya, Rivera-Nieves Jesus, Moskaluk Christopher A., Matsumoto Satoshi, Kozaiwa Kosuke, Cominelli Fabio, Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease, Journal of Clinical Investigation, 107, 6, 2001. Crossref

  21. Bukovsky A., Immune Maintenance of Self in Morphostasis of Distinct Tissues, Tumour Growth and Regenerative Medicine, Scandinavian Journal of Immunology, 73, 3, 2011. Crossref

  22. Wang Tian, Alam Raeful, Langley Keith E., Klimpel Gary R., Stem Cell Factor and IL-2 Act Synergistically in Inducing Intraepithelial Lymphocyte Proliferation and Cytokine Production: Upregulation of the IL-2 Receptor γ-Chain and Signaling via JAK-3, Cellular Immunology, 205, 1, 2000. Crossref

  23. Claude Lambert, Mohammad Ibrahim, Cristina Iobagiu, Christian Genin, Significance of Unconventional Peripheral CD4+CD8dim T Cell Subsets, Journal of Clinical Immunology, 2005. Crossref

  24. Rydell Niclas, Stertman Linda, Sjöholm Ingvar, Starch microparticles as vaccine adjuvant, Expert Opinion on Drug Delivery, 2, 5, 2005. Crossref

  25. Ogata Masaki, Ota Yuta, Nanno Masanobu, Suzuki Ryuji, Itoh Tsunetoshi, Activation of intra-epithelial lymphocytes; their morphology, marker expression and ultimate fate, Cell and Tissue Research, 356, 1, 2014. Crossref

  26. Isse Kumiko, Harada Kenichi, Sato Yasunori, Nakanuma Yasuni, Characterization of biliary intra-epithelial lymphocytes at different anatomical levels of intrahepatic bile ducts under normal and pathological conditions: Numbers of CD4+CD28- intra-epithelial lymphocytes are increased in primary biliary cirrhosis, Pathology International, 56, 1, 2006. Crossref

  27. Bukovsky Antonin, Caudle Michael R., Virant-Klun Irma, Gupta Satish K., Dominguez Roberto, Svetlikova Marta, Xu Fei, Immune physiology and oogenesis in fetal and adult humans, ovarian infertility, and totipotency of adult ovarian stem cells, Birth Defects Research Part C: Embryo Today: Reviews, 87, 1, 2009. Crossref

  28. Yang Hua, Feng Yongjia, Sun Xiaoyi, Teitelbaum Daniel H., Enteral versus Parenteral Nutrition: Effect on Intestinal Barrier Function, Annals of the New York Academy of Sciences, 1165, 1, 2009. Crossref

  29. Dikov Dorian, Bachurska Svitlana, Staikov Dimitri, Sarafian Victoria, Intraepithelial lymphocytes in relation to NIH category IV prostatitis in autopsy prostate, The Prostate, 75, 10, 2015. Crossref

  30. Bukovsky Antonin, Copas Pleas, Virant-Klun Irma, Potential new strategies for the treatment of ovarian infertility and degenerative diseases with autologous ovarian stem cells, Expert Opinion on Biological Therapy, 6, 4, 2006. Crossref

  31. Ogata Masaki, Ota Yuta, Nanno Masanobu, Suzuki Ryuji, Itoh Tsunetoshi, Autocrine DNA fragmentation of intra-epithelial lymphocytes (IELs) in mouse small intestine, Cell and Tissue Research, 361, 3, 2015. Crossref

  32. Davidson S.R., Hoffman-Goetz L., Freewheel running selectively prevents mouse CD4+ intestinal lymphocyte death produced after a bout of acute strenuous exercise, Brain, Behavior, and Immunity, 20, 2, 2006. Crossref

  33. Toth Stefan, Jonecova Zuzana, Kruzliak Peter, Ciccocioppo Rachele, Nemcova Radomira, Influence of dietary supplementation with flaxseed and lactobacilli on the cells of local innate immunity response in the jejunal mucosa in piglets after weaning, Acta Histochemica, 117, 2, 2015. Crossref

  34. Hoffman-Goetz L., Pervaiz N., Guan J., Voluntary exercise training in mice increases the expression of antioxidant enzymes and decreases the expression of TNF-α in intestinal lymphocytes, Brain, Behavior, and Immunity, 23, 4, 2009. Crossref

  35. Lee Chang-Hyun, Youn Young, Song Geun-Seoub, Kim Young-Soo, Immunostimulatory Effects of Traditional Doenjang, Journal of the Korean Society of Food Science and Nutrition, 40, 9, 2011. Crossref

  36. Cairo Cristiana, Armstrong Cheryl L., Cummings Jean Saville, Deetz Carl O., Tan Ming, Lu Changwan, Davis Charles E., Pauza C. David, Impact of age, gender, and race on circulating γδ T cells, Human Immunology, 71, 10, 2010. Crossref

  37. Mackay Ian R., Rosen Fred S., Delves Peter J., Roitt Ivan M., The Immune System, New England Journal of Medicine, 343, 2, 2000. Crossref

  38. Eisenbraun Michael D., Development, function and maintenance of T lymphocyte populations in P-glycoprotein-deficient mice, Clinical and Applied Immunology Reviews, 4, 1, 2003. Crossref

  39. Das Gobardhan, Janeway Charles A, MHC specificity of iIELs, Trends in Immunology, 24, 2, 2003. Crossref

  40. Kurtz Courtney C., Carey Hannah V., Seasonal changes in the intestinal immune system of hibernating ground squirrels, Developmental & Comparative Immunology, 31, 4, 2007. Crossref

  41. Wildhaber Barbara E., Yang Hua, Spencer Ariel U., Drongowski Robert A., Teitelbaum Daniel H., Lack of enteral nutrition—effects on the intestinal immune system, Journal of Surgical Research, 123, 1, 2005. Crossref

  42. Hoffman-Goetz L., Pervaiz N., Packer N., Guan J., Freewheel training decreases pro- and increases anti-inflammatory cytokine expression in mouse intestinal lymphocytes, Brain, Behavior, and Immunity, 24, 7, 2010. Crossref

  43. Bukovsky A., Caudle M.R., Wimalasena J., Keenan J.A., Elder R.F., The role of the host–tumor interface and cell hybridization in invasive cancer, Medical Hypotheses, 57, 6, 2001. Crossref

  44. van Pel Melissa, van Breugel Danielle W.J.G., van Wijk Margot, Luypen Sacco, Vingerhoed Jose, Roholl Paul J.M., Boog Claire J.P., Donor-specific tolerance in a murine model: the result of extra-thymic T cell deletion?, Transplant Immunology, 11, 3-4, 2003. Crossref

  45. Quadrilatero J., Hoffman-Goetz L., N-Acetyl-l-cysteine prevents exercise-induced intestinal lymphocyte apoptosis by maintaining intracellular glutathione levels and reducing mitochondrial membrane depolarization, Biochemical and Biophysical Research Communications, 319, 3, 2004. Crossref

  46. Kellersmann Richard, Ulrichs Karin, Kellersmann Anne, Thiede Arnulf, Intragraft distribution of lymphocytes expressing β7 integrins after small bowel transplantation in mice, Transplant Immunology, 13, 4, 2004. Crossref

  47. Shi Meiqing, Huther Stefanie, Burkhardt Eberhard, Zahner Horst, Lymphocyte subpopulations in the caecum mucosa of rats after infections with Eimeria separata: early responses in naive and immune animals to primary and challenge infections, International Journal for Parasitology, 31, 1, 2001. Crossref

  48. Bukovsky A., Caudle M.R., Keenan J.A., Dominant role of monocytes in control of tissue function and aging, Medical Hypotheses, 55, 4, 2000. Crossref

  49. Solano-Aguilar Gloria I., Vengroski Kelly G., Beshah Ethiopia, Douglass Larry W., Lunney Joan K., Characterization of lymphocyte subsets from mucosal tissues in neonatal swine, Developmental & Comparative Immunology, 25, 3, 2001. Crossref

  50. Horio Yoshiaki, Osawa Satoshi, Takagaki Kousuke, Hishida Akira, Furuta Takahisa, Ikuma Mutsuhiro, Glutamine supplementation increases Th1-cytokine responses in murine intestinal intraepithelial lymphocytes, Cytokine, 44, 1, 2008. Crossref

  51. Eisenbraun Michael D, Mosley R.Lee, Teitelbaum Daniel H, Miller Richard A, Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient mice, Developmental & Comparative Immunology, 24, 8, 2000. Crossref

  52. McCluskie Michael J., Davis Heather L., Mucosal immunization with DNA vaccines, Microbes and Infection, 1, 9, 1999. Crossref

  53. Lee Chi-Jen, Lee Lucia H., Gu Xin-Xing, Mucosal Immunity Induced by Pneumococcal Glycoconjugate, Critical Reviews in Microbiology, 31, 3, 2005. Crossref

  54. Ogata Masaki, Itoh Tsunetoshi, Gamma/delta intraepithelial lymphocytes in the mouse small intestine, Anatomical Science International, 91, 4, 2016. Crossref

  55. Cima Igor , Corazza Nadia , Dick Bernhard , Fuhrer Andrea , Herren Simon , Jakob Sabine , Ayuni Erick , Mueller Christoph , Brunner Thomas , Intestinal Epithelial Cells Synthesize Glucocorticoids and Regulate T Cell Activation , Journal of Experimental Medicine, 200, 12, 2004. Crossref

  56. Li Renjun, Ma Yanfen, Zhai Lijuan, Lu Yisong, Chi Xiaoqing, Wu Jiusheng, Hu Songhua, Enhanced immune response to foot-and-mouth disease vaccine by oral administration of ginseng stem-leaf saponins, Immunopharmacology and Immunotoxicology, 38, 4, 2016. Crossref

  57. Liu Lili, Fu Chenxing, Yan Mingli, Xie Hongbing, Li Si, Yu Qifang, He Shaoping, He Jianhua, Resveratrol modulates intestinal morphology and HSP70/90, NF-κB and EGF expression in the jejunal mucosa of black-boned chickens on exposure to circular heat stress, Food & Function, 7, 3, 2016. Crossref

  58. Séguier Sylvie, Godeau Gaston, Leborgne Michelle, Pivert Gérard, Brousse Nicole, Immunohistologic and Morphometric Analysis of Cytotoxic T Lymphocytes in Gingivitis, Journal of Periodontology, 70, 11, 1999. Crossref

  59. Linehan John D., Kolios George, Valatas Vassilis, Robertson Duncan A. F., Westwick John, Effect of corticosteroids on nitric oxide production in inflammatory bowel disease: are leukocytes the site of action?, American Journal of Physiology-Gastrointestinal and Liver Physiology, 288, 2, 2005. Crossref

  60. Bukovsky Antonin, Cekanova Maria, Caudle Michael R., Wimalasena Jay, Foster James S., Keenan Jeffrey A., Elder Robert F., Variability of Placental Expression of Cyclin E Low Molecular Weight Variants1, Biology of Reproduction, 67, 2, 2002. Crossref

  61. Robles E. Franco, Vázquez V. Pérez, Emiliano J. Ramírez, Amaro R. González, Briones S. López, High fat diet induces alterations to intraepithelial lymphocyte and cytokine mRNA in the small intestine of C57BL/6 mice, RSC Advances, 7, 9, 2017. Crossref

  62. Brunner T, Arnold D, Wasem C, Herren S, Frutschi C, Regulation of cell death and survival in intestinal intraepithelial lymphocytes, Cell Death & Differentiation, 8, 7, 2001. Crossref

  63. Dong Li, Zhong Xiang, Ahmad Hussain, Li Wei, Wang Yuanxiao, Zhang Lili, Wang Tian, Intrauterine Growth Restriction Impairs Small Intestinal Mucosal Immunity in Neonatal Piglets, Journal of Histochemistry & Cytochemistry, 62, 7, 2014. Crossref

  64. Hoffman-Goetz L., Quadrilatero J., Boudreau J., Guan J., Adrenalectomy in mice does not prevent loss of intestinal lymphocytes after exercise, Journal of Applied Physiology, 96, 6, 2004. Crossref

  65. Yang Hua, Madison Blair, Gumucio Deborah L., Teitelbaum Daniel H., Specific overexpression of IL-7 in the intestinal mucosa: the role in intestinal intraepithelial lymphocyte development, American Journal of Physiology-Gastrointestinal and Liver Physiology, 294, 6, 2008. Crossref

  66. Douzandeh-Mobarrez Banafsheh, Kariminik Ashraf, Gut Microbiota and IL-17A: Physiological and Pathological Responses, Probiotics and Antimicrobial Proteins, 11, 1, 2019. Crossref

  67. Suzuki Ryuyo, Nakao Atsuhito, Kanamaru Yutaka, Okumura Ko, Ogawa Hideoki, Ra Chisei, Localization of intestinal intraepithelial T lymphocytes involves regulation of αEβ7 expression by transforming growth factor‐β, International Immunology, 14, 4, 2002. Crossref

  68. LEITE Christiane Araujo Chaves, FAGUNDES-NETO Ulysses, HAAPALAINEN Edna Freymüller, EVALUATION OF THE ULTRASTRUCTURE OF THE SMALL INTESTINE OF HIV INFECTED CHILDREN BY TRANSMISSION AND SCANNING ELECTRONIC MICROSCOPY, Arquivos de Gastroenterologia, 50, 1, 2013. Crossref

  69. Hayday Adrian, Theodoridis Efstathios, Ramsburg Elizabeth, Shires John, Intraepithelial lymphocytes: exploring the Third Way in immunology, Nature Immunology, 2, 11, 2001. Crossref

  70. Ikezawa Fumie, Fukatsu Kazuhiko, Moriya Tomoyuki, Maeshima Yoshinori, Okamoto Koichi, Hara Etsuko, Hiraide Hoshio, Albumin Infusion After Reperfusion Prevents Gut Ischemia-Reperfusion-Induced Gut-Associated Lymphoid Tissue Atrophy, Journal of Parenteral and Enteral Nutrition, 30, 5, 2006. Crossref

  71. Bukovsky Antonin, Novel Immunological Aspects for the Treatment of Age-induced Ovarian and Testicular Infertility, Other Functional Diseases, and Early and Advanced Cancer Immunotherapy, in Human Reproduction, 2016. Crossref

  72. Montalban-Arques A, Chaparro M, Gisbert Javier P, Bernardo D, The Innate Immune System in the Gastrointestinal Tract: Role of Intraepithelial Lymphocytes and Lamina Propria Innate Lymphoid Cells in Intestinal Inflammation, Inflammatory Bowel Diseases, 24, 8, 2018. Crossref

  73. Lee Peter P., Yee Cassian, Savage Peter A., Fong Lawrence, Brockstedt Dirk, Weber Jeffrey S., Johnson Denise, Swetter Susan, Thompson John, Greenberg Philip D., Roederer Mario, Davis Mark M., Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients, Nature Medicine, 5, 6, 1999. Crossref

  74. Park Eun Jeong, Takahashi Ichiro, Ikeda Junko, Kawahara Kazuko, Okamoto Tetsuji, Kweon Mi-Na, Fukuyama Satoshi, Groh Veronika, Spies Thomas, Obata Yuichi, Miyazaki Jun-Ichi, Kiyono Hiroshi, Clonal Expansion of Double-Positive Intraepithelial Lymphocytes by MHC Class I-Related Chain A Expressed in Mouse Small Intestinal Epithelium, The Journal of Immunology, 171, 8, 2003. Crossref

  75. Hodin Richard A., Matthews Jeffrey B., Small Intestine, in Surgery, 2001. Crossref

  76. Qu Lin-Lin, Lyu Ya-Qing, Jiang Hai-Tao, Shan Ting, Zhang Jing-Bin, Li Qiu-Rong, Li Jie-Shou, Effect of Alemtuzumab on Intestinal Intraepithelial Lymphocytes and Intestinal Barrier Function in Cynomolgus Model, Chinese Medical Journal, 128, 5, 2015. Crossref

  77. Campbell Eric L., Serhan Charles N., Colgan Sean P., Antimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators, The Journal of Immunology, 187, 7, 2011. Crossref

  78. Sun Lihua, Li Teming, Tang Hanlin, Yu Kun, Ma Yuanhang, Yu Min, Qiu Yuan, Xu Pengyuan, Xiao Weidong, Yang Hua, Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1α Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes, Frontiers in Immunology, 10, 2019. Crossref

  79. QUADRILATERO JOE, HOFFMAN-GOETZ LAURIE, N-Acetyl-L-Cysteine Inhibits Exercise-Induced Lymphocyte Apoptotic Protein Alterations, Medicine & Science in Sports & Exercise, 37, 1, 2005. Crossref

  80. FUJIOKA Mari, SASA Ryuji, INOUE Mitsuko, NAKAMURA Masanori, Immunological Characterization of Junctional Epithelium: An Immunohistochemical Study, Dental Medicine Research, 29, 3, 2009. Crossref

  81. Todd Derrick J., Greiner Dale L., Rossini Aldo A., Mordes John P., Bortell Rita, An Atypical Population of NK Cells That Spontaneously Secrete IFN-γ and IL-4 Is Present in the Intraepithelial Lymphoid Compartment of the Rat, The Journal of Immunology, 167, 7, 2001. Crossref

  82. Beagley Kenneth W., Newcombe Nicole, Wu Zhong Ling, Gockel Christine M., Bao Shisian, Holland Michael J., Jones Russell C., Immunoglobulin Entry into the Male Reproductive Tract: Implications for immunocontraception and vaccine development, in Reproductive Immunology, 1999. Crossref

  83. Sundaram Susinder, Nithyanand Paramasivam, Naushad Shaik Mohammad, Kutala Nikhita, Kutala Vijay Kumar, Stem Cell Therapy in Premature Ovarian Failure, in Stem Cell Therapy for Organ Failure, 2014. Crossref

  84. Rundle Andrew, Mechanisms Underlying the Effects of Physical Activity on Cancer, in Physical Activity, Dietary Calorie Restriction, and Cancer, 2011. Crossref

  85. Müller Stefan, Bühler-Jungo Myriam, Mueller Christoph, Intestinal Intraepithelial Lymphocytes Exert Potent Protective Cytotoxic Activity During an Acute Virus Infection, The Journal of Immunology, 164, 4, 2000. Crossref

  86. McCormick Beth A., Signal Transduction in the Intestinal Mucosa, in Colonization of Mucosal Surfaces, 2014. Crossref

  87. Colgan Sean P., Furuta Glenn T., Taylor Cormac T., Cytokines and Epithelial Function, in Microbial Pathogenesis and the Intestinal Epithelial Cell, 2014. Crossref

  88. Corps Elaine, Carter Christine, Karecla Paula, Ahrens Thomas, Evans Paul, Kilshaw Peter, Recognition of E-cadherin by Integrin αEβ7, Journal of Biological Chemistry, 276, 33, 2001. Crossref

  89. Mysorekar Indira U., Lorenz Robin G., Gordon Jeffrey I., A Gnotobiotic Transgenic Mouse Model for Studying Interactions between Small Intestinal Enterocytes and Intraepithelial Lymphocytes, Journal of Biological Chemistry, 277, 40, 2002. Crossref

  90. Ciccocioppo R, Di Sabatino A, Parroni R, D’Alò S, Pistoia M A, Doglioni C, Cifone M G, Corazza G R, Cytolytic mechanisms of intraepithelial lymphocytes in coeliac disease (CoD), Clinical and Experimental Immunology, 120, 2, 2001. Crossref

  91. Souza Cleverson D., McEntire Meredeth, Valli V.E. Ted, Jacobs Robert M., Structure and Function of Primary and Secondary Lymphoid Tissue, in Schalm's Veterinary Hematology, 2022. Crossref

  92. Hidaka Mayumi, Nakamura Masanori, Ohmichi Yukari, Itoh Jun, Fukuzawa Kenji, Masuko Takashi, Yagi Hideki, Involvement of intestinal intraepithelial lymphocytes in turnover of intestinal epithelial cells: Morphological and functional alterations due to daily administration of FK506, Cellular Immunology, 279, 2, 2012. Crossref

  93. Brest Patrick, Mograbi Baharia, Hofman Véronique, Loubat Agnès, Rossi Bernard, Auberger Patrick, Hofman Paul, Rho GTPase Is Activated by Cytotoxic Necrotizing Factor 1 in Peripheral Blood T Lymphocytes: Potential Cytotoxicity for Intestinal Epithelial Cells, Infection and Immunity, 71, 3, 2003. Crossref

  94. Nedospasov S. A., Kuprash D. V., Oncoimmunology: Some fundamental problems of cancer immunotherapy, Molecular Biology, 41, 2, 2007. Crossref

  95. Miller C., Roberts S. J., Ramsburg E., Hayday A. C., γδ cells in got infection, immunopathology, and organogenesis, Springer Seminars in Immunopathology, 22, 3, 2000. Crossref

  96. Chu Ching-Liang, Chen Shih-Shun, Wu Tzong-Shoon, Kuo Szu-Cheng, Liao Nan-Shih, Differential Effects of IL-2 and IL-15 on the Death and Survival of Activated TCRγδ+ Intestinal Intraepithelial Lymphocytes, The Journal of Immunology, 162, 4, 1999. Crossref

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