Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Tumor Necrosis Factor: Function, Release and Clearance
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RÉSUMÉ
Tumor Necrosis Factor (TNF) is a multifunctional cytokine. It plays an important role in the pathophysiology of several diseases. Recently, it has been discovered that TNF is circulating in two different forms, a bioactive form and an immunologically detectable form. These two forms of TNF show different clearance kinetics. The immunological form is supposed to be an inactivated TNF protein. For this inactivation, proteolytic degradation or TNF binding by inactivating proteins is necessary. In this review we have focused on TNF inactivation by TNF binding proteins. Recent data show that there are soluble TNF receptors circulating which can bind and inactivate TNF. These receptors are membrane-bound TNF receptors which have been proteolytically cleaved from the cell membrane. Two TNF receptors are circulating, the soluble TNF receptor of 55 kDa (P55) and the receptor of 75 kDa (P75). The receptors are held responsible not only for inactivation of the TNF, but also for the clearance of TNF. Recent data show that the kidney is the most important organ for TNF clearance, followed by the liver. All other organs are of less importance. In this review, function, release, and clearance of TNF are discussed.
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Al-Hatamleh Mohammad A. I., Ahmad Suhana, Boer Jennifer C., Lim JitKang, Chen Xin, Plebanski Magdalena, Mohamud Rohimah, A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy, Journal of Oncology, 2019, 2019. Crossref
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Salazar Alberto, Casanova-Méndez Israel, Pacheco-Quito Michele, Velázquez-Soto Henry, Ayala-Balboa Julio, Graue-Hernández Enrique, Serafín-López Jeanet, Jiménez-Martínez María, Low Expression of IL-10 in Circulating Bregs and Inverted IL-10/TNF-α Ratio in Tears of Patients with Perennial Allergic Conjunctivitis: A Preliminary Study, International Journal of Molecular Sciences, 20, 5, 2019. Crossref
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Ng Kevin W, Attig Jan, Young George R, Ottina Eleonora, Papamichos Spyros I, Kotsianidis Ioannis, Kassiotis George, Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist, eLife, 8, 2019. Crossref
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Ihara Katsuhito, Skupien Jan, Krolewski Bozena, Md Dom Zaipul I., O’Neil Kristina, Satake Eiichiro, Kobayashi Hiroki, Rashidi Narges M., Niewczas Monika A., Krolewski Andrzej S., A profile of multiple circulating tumor necrosis factor receptors associated with early progressive kidney decline in Type 1 Diabetes is similar to profiles in autoimmune disorders, Kidney International, 99, 3, 2021. Crossref
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Chen Teresa K., Coca Steven G., Estrella Michelle M., Appel Lawrence J., Coresh Josef, Thiessen Philbrook Heather, Obeid Wassim, Fried Linda F., Heerspink Hiddo J.L., Ix Joachim H., Shlipak Michael G., Kimmel Paul L., Parikh Chirag R., Grams Morgan E., Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D, Journal of the American Society of Nephrology, 33, 5, 2022. Crossref
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Xu Yue, Li Hao-Yu, Cai Lang, Xie Shi-Chen, Zou Yang, Zhu Xing-Quan, Zheng Wen-Bin, Differential Spleen miRNA Expression Profile of Beagle Dogs Infected with Toxocara canis, Animals, 12, 19, 2022. Crossref