Publication de 4 numéros par an
ISSN Imprimer: 1050-6934
ISSN En ligne: 1940-4379
Indexed in
Platinum Concentration and Platinum Oxidation States in Body Fluids, Tissue, and Explants from Women Exposed to Silicone and Saline Breast Implants
RÉSUMÉ
Comments on a previous study necessitate a response on our part. Descriptive statistics were the most appropriate statistical tool for data analysis, given the small number of samples studied, and conclusions based on inferential statistics applied to the control subsets would have been inappropriate. Cross-study comparisons and drawing conclusions based on the published literature are commonly used standard methods for exposure analysis and interpretation. No oxidation artifacts were observed for the digestion conditions used. Since standards only exist for Pt 0, +2, and +4, Pt +1, +3, +5, and +6 were inferred. We hypothesize that the catalyst may be deteriorating due to the interaction at 37°C with miscelles of mainly unsaturated fatty acids. The miscelles, through hydro-phobicity, may dissociate the aged Pt catalyst from the silicone cross-linkage and facilitate migration into the tissues. The conclusions, that the study was the most comprehensive report to show that women exposed to silicone breast implants have Pt levels that exceed that of the general population, and the first report to show oxidized forms of Pt present in samples from exposed women, are entirely supported by the data and are robust.
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Kashi A., Saha S., Mechanisms of failure of medical implants during long-term use, in Biointegration of Medical Implant Materials, 2010. Crossref
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Schierl Rudolf, Lemmer Anke, Bo¨hlandt Antje, Friedl Lilia, Haneder Sebastian, Nowak Dennis, Silicone implants – a possible confounder for urinary platinum background concentrations?, Environmental Research, 132, 2014. Crossref
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Lepage Nadège, Canal-Raffin Mireille, Villa Antoine, Propositions pour la mise en œuvre d’une surveillance biologique de l’exposition professionnelle aux médicaments anticancéreux, Toxicologie Analytique et Clinique, 29, 4, 2017. Crossref
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Rentschler Gerda, Rodushkin Ilia, Cerna Milena, Chen Chunying, Harari Florencia, Harari Raúl, Horvat Milena, Hruba Frantiska, Kasparova Lucie, Koppova Kvetoslava, Krskova Andrea, Krsnik Mladen, Laamech Jawhar, Li Yu-Feng, Löfmark Lina, Lundh Thomas, Lundström Nils-Göran, Lyoussi Badiaa, Mazej Darja, Osredkar Josko, Pawlas Krystyna, Pawlas Natalia, Prokopowicz Adam, Skerfving Staffan, Snoj Tratnik Janja, Spevackova Vera, Spiric Zdravko, Sundkvist Anneli, Strömberg Ulf, Vadla Drazenka, Wranova Katerina, Zizi Soumia, Bergdahl Ingvar A., Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries, International Journal of Hygiene and Environmental Health, 221, 2, 2018. Crossref