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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Imprimer: 2151-8017
ISSN En ligne: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2012006134
pages 169-182

A Role for Nitric Oxide and for Nitric Oxide Synthases in Tumor Biology

Graciele A. de Oliveira
Departamento de Bioquimica/Biologia Molecular, Centro de Terapia Celular e Molecular, Universidade Federal de Sao Paulo, Campus Sao Paulo, Sao Paulo, Brazil
Heloisa Rosa
Departamento de Bioquimica/Biologia Molecular, Centro de Terapia Celular e Molecular, Universidade Federal de Sao Paulo, Campus Sao Paulo, Sao Paulo, Brazil
Adriana Karla C.A. Reis
Departamento de Ciencias Exatas e da Terra, Universidade Federal de Sao Paulo, Campus Diadema, Sao Paulo, Brazil
Arnold Stern
Department of Pharmacology, New York University School of Medicine, New York, NY
Hugo P. Monteiro
Departamento de Bioquimica/Biologia Molecular, Centro de Terapia Celular e Molecular, Universidade Federal de Sao Paulo, Campus Sao Paulo, Sao Paulo, Brazil

RÉSUMÉ

The dual role of nitric oxide in cancer biology is discussed here through the perspective of our work on nitric oxide−mediated signaling events. The nitric oxide-stimulated Src-FAK and Ras-ERK1/2 mitogen-activated protein kinases (MAPKs) oncogenic signaling pathways are discussed, highlighting the cross-talk between 2 major posttranslational modifications: protein phosphorylation and protein S-nitrosylation. In addition, we discuss the importance of nitric oxide synthases in cancer biology, focusing on the roles of endothelial nitric oxide synthase and arginase 2 in human thyroid tumor progression. A direct relationship between the expression levels of both enzymes was found in human follicular thyroid carcinoma. Finally, the antioncogenic, proapoptotic actions of nitric oxide based on its anti-adhesive properties are presented and discussed.