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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Dose-Dependent Effects of Ethanol on Lead-Induced Oxidative Stress in Rats

Volume 31, Numéro 1, 2012, pp. 61-73
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i1.70
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RÉSUMÉ

This study explored the dose-dependent effects of ethanol ingestion during co-exposure with lead in rats. Lead was administered orally, once daily at a dose of 10 mg/kg whereas ethanol was given in drinking water at 3 different doses: 1%, 2%, and 5% along with lead. The exposure continued for 3 months, after which the animals were decapitated and various biochemical assays were carried out. The results show increased oxidative stress in animals co-exposed to lead and ethanol compared with either lead or ethanol alone. A significant decrease in blood δ-aminolevulinic acid dehydratase activity, glutathione (GSH), GSH peroxidase, adenosine triphosphatase, and catalase but a significant increase in reactive oxygen species, oxidized GSH, thiobarbituric acid reactive substance, and intracellular calcium was noted in lead and ethanol co-exposed animals. The changes were found to be dose dependent in lead plus ethanol exposed animals. Decrease in glucose-6-phosphate dehydrogenase activity in blood was noted, with no significant changes in liver and kidney. Aldehyde dehdrogenase activity decreased significantly in animals exposed to either lead or ethanol but a pronounced depletion was seen in rats co-exposed to lead and ethanol (5%). The results suggest that the combined exposure to lead and ethanol leads to increased oxidative stress and possible initiation of apoptosis in rats.

CITÉ PAR
  1. Flora Gagan, Gupta Deepesh, Tiwari Archana, Preventive Efficacy of Bulk and Nanocurcumin Against Lead-Induced Oxidative Stress in Mice, Biological Trace Element Research, 152, 1, 2013. Crossref

  2. Virgolini Miriam B., Mattalloni Mara S., Albrecht Paula A., Deza-Ponzio Romina, Cancela Liliana M., Modulation of Ethanol-Metabolizing Enzymes by Developmental Lead Exposure: Effects in Voluntary Ethanol Consumption, Frontiers in Behavioral Neuroscience, 11, 2017. Crossref

  3. Virgolini Miriam B., Mattalloni Mara S., Deza-Ponzio Romina, Albrecht Paula A., Cancela Liliana M., Lead Exposure and Ethanol Intake: Oxidative Stress as a Converging Mechanism of Action, in Neuroscience of Alcohol, 2019. Crossref

  4. Zahid Mohd, Rawat Pushkar Singh, Singh Shalini, Gupta Akshay Kumar, Ahmad Rumana, Mahdi Abbas Ali, Ahmad Md. Kaleem, Mehrotra Sudhir, Assessment of Role and Efficacy of Curcumin and Quercetin in Preventing Lead-Induced Oxidative Stress in Rats, Indian Journal of Clinical Biochemistry, 37, 3, 2022. Crossref

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