Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Dose-Dependent Effects of Ethanol on Lead-Induced Oxidative Stress in Rats
RÉSUMÉ
This study explored the dose-dependent effects of ethanol ingestion during co-exposure with lead in rats. Lead was administered orally, once daily at a dose of 10 mg/kg whereas ethanol was given in drinking water at 3 different doses: 1%, 2%, and 5% along with lead. The exposure continued for 3 months, after which the animals were decapitated and various biochemical assays were carried out. The results show increased oxidative stress in animals co-exposed to lead and ethanol compared with either lead or ethanol alone. A significant decrease in blood δ-aminolevulinic acid dehydratase activity, glutathione (GSH), GSH peroxidase, adenosine triphosphatase, and catalase but a significant increase in reactive oxygen species, oxidized GSH, thiobarbituric acid reactive substance, and intracellular calcium was noted in lead and ethanol co-exposed animals. The changes were found to be dose dependent in lead plus ethanol exposed animals. Decrease in glucose-6-phosphate dehydrogenase activity in blood was noted, with no significant changes in liver and kidney. Aldehyde dehdrogenase activity decreased significantly in animals exposed to either lead or ethanol but a pronounced depletion was seen in rats co-exposed to lead and ethanol (5%). The results suggest that the combined exposure to lead and ethanol leads to increased oxidative stress and possible initiation of apoptosis in rats.
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Virgolini Miriam B., Mattalloni Mara S., Deza-Ponzio Romina, Albrecht Paula A., Cancela Liliana M., Lead Exposure and Ethanol Intake: Oxidative Stress as a Converging Mechanism of Action, in Neuroscience of Alcohol, 2019. Crossref
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Zahid Mohd, Rawat Pushkar Singh, Singh Shalini, Gupta Akshay Kumar, Ahmad Rumana, Mahdi Abbas Ali, Ahmad Md. Kaleem, Mehrotra Sudhir, Assessment of Role and Efficacy of Curcumin and Quercetin in Preventing Lead-Induced Oxidative Stress in Rats, Indian Journal of Clinical Biochemistry, 37, 3, 2022. Crossref