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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Chemopreventive Potential of an Indian Medicinal Plant (Tinospora cordifolia) on Skin Carcinogenesis in Mice

Volume 27, Numéro 3, 2008, pp. 233-243
DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i3.70
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RÉSUMÉ

Tinospora cordifolia (Guduchi), an Indian medicinal plant, was used to explore antitumor promoting activity in a two-stage skin carcinogenesis model. For this purpose, mice were treated by single application of DMBA (100 μg/100 μl of acetone) and two weeks later promoted by croton oil (1% in acetone three times a week) until the end of the experiment (i.e., 16 weeks). Oral administration of the above extract at the preinitiational stage (i.e., seven days before and seven days after DMBA application; group IV), promotional stage (i.e., from the time of croton oil application; group V), and both pre- and postintiational stage (i.e., from the time of DMBA application and continued until the end of the experiment; group VI; on the shaven backs of the mice at the dose of 100 mg/kg body weight/day for 16 weeks) recorded significant reduction in tumor weight, tumor incidence in comparison to control (i.e., mice treated with DMBA and croton oil; group III). Furthermore, cumulative number of papillomas, tumor yield, tumor burden, and tumor weight showed significant reduction along with significant elevation of phase II detoxifying enzymes, and inhibition of lipid peroxidation in liver and skin in the animals administered with such plant extract concomitant to carcinogen exposure. Thus, the present data strongly suggests that the Tinospora cordifolia extract has anti-tumor potential in a two-stage skin carcinogenesis mouse model.

CITÉ PAR
  1. Hafidh Rand R., Abas Faridah, Abdulamir Ahmed S., Jahanshiri Fatemeh, Bakar Fatimah Abu, Sekawi Zamberi, A Review: Cancer Research of Natural Products in Asia, International Journal of Cancer Research, 5, 2, 2009. Crossref

  2. Amir Mohd, Haque Md. Anzarul, Wahiduzzaman , Dar Mohammad Aasif, Islam Asimul, Ahmad Faizan, Hassan Md. Imtaiyaz, Purification and characterization of oligonucleotide binding (OB)-fold protein from medicinal plant Tinospora cordifolia, Journal of Chromatography B, 1008, 2016. Crossref

  3. Jahan Swafiya, Chaudhary Ranu, Goyal Pradeep Kumar, Anticancer Activity of an Indian Medicinal Plant, Alstonia scholaris, on Skin Carcinogenesis in Mice, Integrative Cancer Therapies, 8, 3, 2009. Crossref

  4. Mishra Rachana, Kaur Gurcharan, Najbauer Joseph, Aqueous Ethanolic Extract of Tinospora cordifolia as a Potential Candidate for Differentiation Based Therapy of Glioblastomas, PLoS ONE, 8, 10, 2013. Crossref

  5. Sharma Neha, Kumar Ashok, Sharma P.R., Qayum Arem, Singh Shashank K., Dutt Prabhu, Paul Satya, Gupta Vivek, Verma M.K., Satti N.K., Vishwakarma R., A new clerodane furano diterpene glycoside from Tinospora cordifolia triggers autophagy and apoptosis in HCT-116 colon cancer cells, Journal of Ethnopharmacology, 211, 2018. Crossref

  6. Agrawal Annapurna, Jahan Swafiya, Soyal Dhanraj, Goyal Ekank, Goyal Pradeep Kumar, Amelioration of Chemical-Induced Skin Carcinogenesis by Aegle marmelos, an Indian Medicinal Plant, Fruit Extract, Integrative Cancer Therapies, 11, 3, 2012. Crossref

  7. Sahin Kazim, Ali Shakir, Sahin Nurhan, Orhan Cemal, Kucuk Omer, Lycopene: Multitargeted Applications in Cancer Therapy, in Natural Products and Cancer Drug Discovery, 2017. Crossref

  8. Alsuhaibani Sultan, Khan Masood A., Immune-Stimulatory and Therapeutic Activity of Tinospora cordifolia: Double-Edged Sword against Salmonellosis, Journal of Immunology Research, 2017, 2017. Crossref

  9. Kaur Gurcharan, Kataria Hardeep, Mishra Rachana, Medicinal Plants as Novel Promising Therapeutics for Neuroprotection and Neuroregeneration, in New Age Herbals, 2018. Crossref

  10. Goyal Shaily, Arora Jaya, Ramawat Kishan G., Biotechnological Approaches to Medicinal Plants of Aravalli Hills: Conservation and Scientific Validation of Biological Activities, in Biotechnology and Biodiversity, 4, 2014. Crossref

  11. Badole Sachin L., Chaudhari Swapnil M., Zanwar Anand A., Tinospora cordifolia (Willd.) Miers. (Menispermaceae): Beneficial Effect on Skin Diseases, in Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013. Crossref

  12. Akbar Shahid, Tinospora cordifolia (Willd.) Miers ex Hook. F. & Thoms (Menispermaceae), in Handbook of 200 Medicinal Plants, 2020. Crossref

  13. Rana Anamika, Anand Jigisha, Tyagi Manjusha, Rai Nishant, Forest-Based Medicinal Plants for Cancer Cure, in Non-Timber Forest Products, 2021. Crossref

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