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Journal of Environmental Pathology, Toxicology and Oncology
Facteur d'impact: 1.241 Facteur d'impact sur 5 ans: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2017024821
pages 309-320

Is It a Protective Factor of Helicobacter pylori Infection in Overall Survival of All Gastric Cancer? Evidence from Meta-Analysis

Fangchao Zheng
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, 810000, China; Department of Medical Oncology, Shouguang Hospital of Traditional Chinese Medicine, Weifang, 261000, China
Zhihua Sun
Department of Medical Oncology, Shouguang People's Hospital, Weifang Medical University, Weifang, 261000, China
Jie Kan
Department of Medical Oncology, Qinghai Provincial People's Hospital, Xining, 810000, China
Jiangxia Yin
Department of Medical Oncology, Shouguang Hospital of T.C.M, 3353 Shengcheng Street, Weifang, 262700, China
Feng Du
Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
Guoshuang Shen
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Ziyi Wang
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Dengfeng Ren
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China
Xiaqing Bao
Department of Medical Oncology, Affiliated Hospital of Qinghai University, Qinghai University, Xining, 810000, China
Jiuda Zhao
Department of Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, China

RÉSUMÉ

Purpose – We aimed to assess whether Helicobacter pylori infection influences prognosis in gastric cancer patients (GC).
Methods – We systematically searched MEDLINE, PubMed, EBSCO, EMBASE, and the Cochrane Library (CENTRAL) Register from inception to June 1, 2017. Overall survival (mean OS) or disease-free survival (mean DFS) in GC patients were calculated using the hazard ratio (HR) and 95% confidence intervals (95% CIs).
Results – In total, 19 articles with 4,321 GC patients were enrolled. Helicobacter pylori infection is associated with longer OS (HR 0.73; 95% CI 0.60–0.89; P < 0.001) and DFS (HR 0.75; 95% CI 0.53–1.07; P = 0.002) in GC patients overall. For our subgroup analysis, the pooled HRs and 95% CIs were as follows: China (OS: HR 0.95; 95% CI 0.63–1.42; P = 0.804 and DFS: HR 0.88; 95% CI 0.50–1.56; P = 0.658), Europe (OS: HR 0.69; 95% CI 0.52–0.92; P = 0.010 and DFS: HR 0.62; 95% CI 0.32–1.17; P = 0.141), United States (OS: HR 0.77: 95% CI 0.56–1.06; P = 0.105), Korea (OS: HR 0.45; 95% CI 0.27–0.75; P = 0.002 and DFS: HR 0.45; 95% CI 0.24–0.83, P = 0.011), and Turkey (OS: HR 0.94; 95% CI 0.52–1.70; P = 0.839 and DFS: HR 0.95; 95% CI 0.53–1.71, P = 0.864). Moreover, for R0 or M0 patients, H. pylori infection is associated with better OS and DFS (P all values < 0.05).
Conclusions – Helicobacter pylori infection has a better prognosis in GC patients from Korea and Europe. Helicobacter pylori infection has no association with prognosis for China, the United States, or Turkey. Also, H. pylori infection has a better prognosis in R0 resection or M0 GC patients.