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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Detection of Human Papillomavirus DNA, Serum p53, and p53 Antibodies in Patients with Cervical Cancer

Volume 21, Numéro 1, 2002, 7 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i1.80
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RÉSUMÉ

Human papillomavirus (HPV) was detected in 85% and 63.6% of patients with invasive cervical cancer and minor cervical abnormalities, respectively. HPV-16 was the dominant type in both groups of women. Because of the high oncogenic potential of HPV-16 and the greater chance of its persistence, a follow-up of cases with minor cervical abnormalities harboring HPV-16 is warranted in order to observe the progression of the lesion. As many as 61.5% of the cases with invasive cervical cancer were found to have higher levels of serum p53 protein than did healthy controls. None of the patients had antibodies against the overexpressed p53. This suggests that, even if mutated, the p53 protein may not be immuno-genic in all cases. An inverse relationship between the presence of HPV and the alteration in p53 expression was observed in 71.43% of the cases. This could mean the loss of p53 function as a result of either HPV-E6-mediated degradation or mutation in the p53 gene.

CITÉ PAR
  1. Dobrzycka B., Terlikowski S.J., Kinalski M., Kowalczuk O., Niklinska W., Chyczewski L., Circulating free DNA and p53 antibodies in plasma of patients with ovarian epithelial cancers, Annals of Oncology, 22, 5, 2011. Crossref

  2. Dobrzycka Bozena, Terlikowski Slawomir J., Mazurek Andrzej, Kowalczuk Oksana, Niklinska Wieslawa, Chyczewski Lech, Kulikowski Marek, Circulating free DNA, p53 antibody and mutations of KRAS gene in endometrial cancer, International Journal of Cancer, 127, 3, 2010. Crossref

  3. Mohamed Ab Mohamed, . Nabil Ali Gad El-hak, . Ayman Tallatt Abbas, Clinical Significance of Serum p53 Antigen in Patients with Hepatocellular Carcinoma, International Journal of Cancer Research, 1, 2, 2005. Crossref

  4. Abdi Kh., . M. Vossoghi, . M.R. Heidari, . K. Kazemi-Zarkuei, . A. Mandegary, Simultaneous and Simple Determination of Four Active Ingredients of a Pesticide Formulation Using Gas Chromatography-Flame Ionization Detector, Pakistan Journal of Biological Sciences, 9, 8, 2006. Crossref

  5. Oh Min-Jeong, Choi Jin-Hyuk, Lee Yong Ho, Lee Jae Kwan, Hur Joon Young, Park Yong Kyun, Lee Kyu Wan, Chough Soo Yong, Saw Ho-Suk, Mutant p53 protein in the serum of patients with cervical carcinoma: correlation with the level of serum epidermal growth factor receptor and prognostic significance, Cancer Letters, 203, 1, 2004. Crossref

  6. BALOGH GABRIELA A., MAILO DANIEL, NARDI HECTOR, CORTE MARIA MARTA, VINCENT ESTEBAN, BARUTTA ELENA, LIZARRAGA GUILLERMO, LIZARRAGA PABLO, MONTERO HECTOR, GENTILI ROBERTO, Serological levels of mutated p53 protein are highly detected at early stages in breast cancer patients, Experimental and Therapeutic Medicine, 1, 2, 2010. Crossref

  7. Shimada Hideaki, Ochiai Takenori, Nomura Fumio, Titration of serump53 antibodies in 1085 patients with various types of malignant tumors, Cancer, 97, 3, 2003. Crossref

  8. Mostaid Md Shaki, Mumu Sadia Biswas, Haque Md Aminul, Sharmin Shahana, Jamiruddin Mohd Raeed, Sayedur Rahman Ghazi Muhammad, Reza Hasan Mahmud, Abdel Ghafar Muhammad Tarek, Elevated serum expression of p53 and association of TP53 codon 72 polymorphisms with risk of cervical cancer in Bangladeshi women, PLOS ONE, 16, 12, 2021. Crossref

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