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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Regulating RNA Binding Motif 5 Gene Expression− A Novel Therapeutic Target for Lung Cancer

Volume 36, Numéro 2, 2017, pp. 99-105
DOI: 10.1615/JEnvironPatholToxicolOncol.2017019366
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RÉSUMÉ

RNA-binding motif protein 5 (RBM5), also known as LUCA-15/H37, is a gene that maps to human chromosome 3p21.3, a critical region that is deleted in a large number of human cancers, of which the majority are lung cancers, and that is predicted to contain one or more tumor suppressor genes (TSGs). RBM5 is a tumor suppressor gene and is most frequently deleted at the earliest stage of lung cancer development. It represents a significant area of recent progress in cancer genomic, cytogenetic, and molecular biological research because of its role in the induction of cell cycle arrest and apoptosis and the regulation of inhibition of in lung cancer metastasis. RBM5 is involved in the suppression of epidermal growth factor receptor (EGFR) expression, thus preventing proliferation, angiogenesis, invasion, and metastasis of lung cancer. In this way it exhibits its tumor suppressive capacity during lung cancer progression. Exploration of RBM5's potential importance in inhibiting tumor metastasis includes downstream players in the RBM5-mediated metastasis suppressor pathway(s). This review highlights the differential expression of the RBM5 tumor suppressor gene which impacts cell proliferation and apoptosis control during lung cancer progression. Regulating RBM5 expression may be a novel therapeutic target for lung cancer.

CITÉ PAR
  1. Wang Qiwei, Wang Fang, Zhong Waisheng, Ling Hang, Wang Jixuan, Cui Jie, Xie Tao, Wen Senli, Chen Jie, RNA-binding protein RBM6 as a tumor suppressor gene represses the growth and progression in laryngocarcinoma, Gene, 697, 2019. Crossref

  2. Xu Yanling , Su Zhenzhong , Li Junyao , Wang Qi , Meng Guangping , Zhang Yu , Yang Wen , Zhang Jie , Gao Peng , Role of RNA‑binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer (Review), Oncology Letters, 2018. Crossref

  3. Deng Biyong, Pan Runsang, Ou Xin, Wang Taizhe, Wang Weiguo, Nie Yingjie, Chen Houping, Mok K. H., LncRNA RBM5-AS1 Promotes Osteosarcoma Cell Proliferation, Migration, and Invasion, BioMed Research International, 2021, 2021. Crossref

  4. Deng Kun, Yao Jingwei, Huang Jialu, Ding Yubo, Zuo Jianhong, Abnormal alternative splicing promotes tumor resistance in targeted therapy and immunotherapy, Translational Oncology, 14, 6, 2021. Crossref

  5. Malhan Deeksha, Basti Alireza, Relógio Angela, Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes, npj Systems Biology and Applications, 8, 1, 2022. Crossref

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